GPR116

Entrez Summary: N/A
UniProt Summary: Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. {ECO:0000250|UniProtKB:G5E8Q8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pharyngeal arch artery morphogenesis
surfactant homeostasis
glomerular filtration
positive regulation of phospholipid biosynthetic process
renal filtration
chemical homeostasis within a tissue
negative regulation of macrophage activation
regulation of phospholipid biosynthetic process
pharyngeal system development
erythrocyte development
positive regulation of phospholipid metabolic process
regulation of macrophage activation
myeloid cell development
artery morphogenesis
energy reserve metabolic process
apical part of cell
positive regulation of lipid biosynthetic process
erythrocyte differentiation
regulation of phospholipid metabolic process
artery development
erythrocyte homeostasis
fat cell differentiation
myeloid cell homeostasis
renal system process
positive regulation of lipid metabolic process
negative regulation of leukocyte activation
glucose homeostasis
carbohydrate homeostasis
regulation of lipid biosynthetic process
tissue homeostasis
negative regulation of cell activation
homeostasis of number of cells
myeloid cell differentiation
energy derivation by oxidation of organic compounds
cytoplasmic vesicle
multicellular organismal homeostasis
anatomical structure homeostasis
regulation of lipid metabolic process
blood vessel morphogenesis
generation of precursor metabolites and energy