GPR124 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR124 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRA2
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25960|25960]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PE1|Q96PE1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR124&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR124|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606823|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:22013897}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 2|
|GPS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of establishment of blood-brain barrier|
|negative regulation of vascular endothelial growth factor signaling pathway|
|negative regulation of cellular response to vascular endothelial growth factor stimulus|
|Wnt signalosome|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|sprouting angiogenesis|
|endothelial cell migration|
|filopodium|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|positive regulation of endothelial cell migration|
|positive regulation of epithelial cell migration|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of cellular response to growth factor stimulus|
|regulation of endothelial cell migration|
|ameboidal-type cell migration|
|positive regulation of Wnt signaling pathway|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|blood vessel morphogenesis|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|blood vessel development|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell surface|
|tube morphogenesis|
|G protein-coupled receptor activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cell development|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|cell-cell signaling|
|negative regulation of signal transduction|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.84|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.81|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.75|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.71|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12117
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR124 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>