GPR124

Gene Information

Official Symbol: ADGRA2
Official Name: adhesion G protein-coupled receptor A2
Aliases and Previous Symbols: N/A
Entrez ID: 25960
UniProt: Q96PE1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:22013897}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloroquine 32μM R08 exp470	-1.84
VHL-ligand-1 20μM R07 exp421	-1.81
Calcium Ionophore 0.4μM R07 exp342	-1.75
Hydroxyurea 100μM R07 exp329	-1.71
Ibrutinib 10μM R08 exp442	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12117
Expression level (log2 read counts): 3.4

Expression Distribution

7tm 2
GPS

regulation of establishment of blood-brain barrier
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
Wnt signalosome
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
sprouting angiogenesis
endothelial cell migration
filopodium
epithelial cell migration
epithelium migration
tissue migration
positive regulation of endothelial cell migration
positive regulation of epithelial cell migration
positive regulation of canonical Wnt signaling pathway
negative regulation of cellular response to growth factor stimulus
regulation of endothelial cell migration
ameboidal-type cell migration
positive regulation of Wnt signaling pathway
regulation of chemotaxis
regulation of epithelial cell migration
regulation of cellular response to growth factor stimulus
regulation of canonical Wnt signaling pathway
regulation of angiogenesis
angiogenesis
regulation of vasculature development
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
blood vessel morphogenesis
cell surface receptor signaling pathway involved in cell-cell signaling
blood vessel development
positive regulation of cell migration
vasculature development
cardiovascular system development
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
cell surface
tube morphogenesis