GPR126 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR126 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRG6
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor G6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57211|57211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SQ4|Q86SQ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR126&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR126|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612243|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). {ECO:0000250|UniProtKB:C6KFA3, ECO:0000269|PubMed:24227709, ECO:0000269|PubMed:26004201}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|7tm 2|
|CUB|
|Pentaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heart trabecula formation|
|trabecula formation|
|laminin binding|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|extracellular matrix binding|
|Schwann cell development|
|heart trabecula morphogenesis|
|Schwann cell differentiation|
|trabecula morphogenesis|
|collagen binding|
|peripheral nervous system development|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|cardiac chamber morphogenesis|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cAMP-mediated signaling|
|cardiac chamber development|
|glial cell differentiation|
|cyclic-nucleotide-mediated signaling|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|gliogenesis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|heart morphogenesis|
|second-messenger-mediated signaling|
|mitochondrion organization|
|heart development|
|G protein-coupled receptor activity|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|neurogenesis|
|cell development|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.96|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.83|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16479
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR126 Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>