GPR126

Entrez Summary: This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009].
UniProt Summary: G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity). {ECO:0000250|UniProtKB:C6KFA3, ECO:0000269|PubMed:24227709, ECO:0000269|PubMed:26004201}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heart trabecula formation
trabecula formation
laminin binding
peripheral nervous system axon ensheathment
myelination in peripheral nervous system
extracellular matrix binding
Schwann cell development
heart trabecula morphogenesis
Schwann cell differentiation
trabecula morphogenesis
collagen binding
peripheral nervous system development
myelination
glial cell development
ensheathment of neurons
axon ensheathment
cardiac chamber morphogenesis
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
cardiac chamber development
glial cell differentiation
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
gliogenesis
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
heart morphogenesis
second-messenger-mediated signaling
mitochondrion organization
heart development
G protein-coupled receptor activity
circulatory system development
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
G protein-coupled receptor signaling pathway
integral component of plasma membrane
neurogenesis
cell development
intracellular signal transduction