GPR161

Entrez Summary: The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
negative regulation of embryonic development
negative regulation of smoothened signaling pathway
ciliary membrane
endocytic vesicle membrane
regulation of smoothened signaling pathway
recycling endosome
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of embryonic development
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
cilium
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of nervous system development
second-messenger-mediated signaling
G protein-coupled receptor activity
regulation of nervous system development
negative regulation of developmental process
negative regulation of multicellular organismal process
negative regulation of signal transduction
G protein-coupled receptor signaling pathway
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
intracellular signal transduction