GPR17 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR17
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2840|2840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13304|Q13304]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603071|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. {ECO:0000269|PubMed:16990797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor serine/threonine kinase binding|
|negative regulation of inflammatory response to antigenic stimulus|
|chemokine receptor activity|
|regulation of inflammatory response to antigenic stimulus|
|positive regulation of Rho protein signal transduction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|positive regulation of Ras protein signal transduction|
|oligodendrocyte differentiation|
|positive regulation of small GTPase mediated signal transduction|
|chemokine-mediated signaling pathway|
|response to chemokine|
|cellular response to chemokine|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|negative regulation of inflammatory response|
|regulation of Rho protein signal transduction|
|negative regulation of immune response|
|glial cell differentiation|
|negative regulation of defense response|
|gliogenesis|
|regulation of Ras protein signal transduction|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|regulation of inflammatory response|
|regulation of small GTPase mediated signal transduction|
|negative regulation of response to external stimulus|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of defense response|
|ion homeostasis|
|cellular homeostasis|
|central nervous system development|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|regulation of immune response|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of response to stress|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.98|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.81|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12318
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR17 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>