GPR17

Gene Information

Official Symbol: GPR17
Official Name: G protein-coupled receptor 17
Aliases and Previous Symbols: N/A
Entrez ID: 2840
UniProt: Q13304
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. {ECO:0000269|PubMed:16990797}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12318
Expression level (log2 read counts): -2.08

Expression Distribution

Screen	Score
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.98
BI-2536 0.001μM R01 exp41	-1.81
GSK461364A 0.1μM R03 exp126	-1.7

7TM GPCR Srsx
7tm 1

receptor serine/threonine kinase binding
negative regulation of inflammatory response to antigenic stimulus
chemokine receptor activity
regulation of inflammatory response to antigenic stimulus
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of Ras protein signal transduction
oligodendrocyte differentiation
positive regulation of small GTPase mediated signal transduction
chemokine-mediated signaling pathway
response to chemokine
cellular response to chemokine
phospholipase C-activating G protein-coupled receptor signaling pathway
negative regulation of inflammatory response
regulation of Rho protein signal transduction
negative regulation of immune response
glial cell differentiation
negative regulation of defense response
gliogenesis
regulation of Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of inflammatory response
regulation of small GTPase mediated signal transduction
negative regulation of response to external stimulus
cellular calcium ion homeostasis
negative regulation of immune system process
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cytokine-mediated signaling pathway
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
regulation of defense response