GPR20

Entrez Summary: N/A
UniProt Summary: Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP. {ECO:0000269|PubMed:18347022}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rucaparib 6.5μM R08 exp520	-2.07
Chloramphenicol 20μM R00 exp13	-1.88

positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of Rho protein signal transduction
receptor complex
regulation of Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
G protein-coupled receptor activity
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
positive regulation of intracellular signal transduction
chemical homeostasis
G protein-coupled receptor signaling pathway
integral component of plasma membrane
homeostatic process
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction