GPR4

Gene Information

Official Symbol: GPR4
Official Name: G protein-coupled receptor 4
Aliases and Previous Symbols: N/A
Entrez ID: 2828
UniProt: P46093
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production. {ECO:0000269|PubMed:12955148, ECO:0000269|PubMed:17462861}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10579
Expression level (log2 read counts): 1.11

Expression Distribution

glomerular mesangial cell development
glomerular mesangial cell differentiation
mesangial cell development
mesangial cell differentiation
pericyte cell differentiation
glomerular mesangium development
angiogenesis involved in wound healing
glomerulus vasculature development
renal system vasculature development
kidney vasculature development
response to acidic pH
positive regulation of Rho protein signal transduction
epithelial cell differentiation involved in kidney development
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
response to pH
cell differentiation involved in kidney development
glomerulus development
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phospholipase C-activating G protein-coupled receptor signaling pathway
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
nephron development
regulation of Rho protein signal transduction
epithelial cell development
connective tissue development
regulation of Ras protein signal transduction
kidney development
positive regulation of cytosolic calcium ion concentration
renal system development
regulation of angiogenesis
angiogenesis
urogenital system development
regulation of vasculature development
regulation of cytosolic calcium ion concentration
regulation of small GTPase mediated signal transduction
blood vessel morphogenesis
cellular calcium ion homeostasis
calcium ion homeostasis