GPR56

Entrez Summary: This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cabazitaxel 0.001μM R05 exp223	-1.74
BRD2 inhibitor II 20μM R07 exp341	-1.71

7tm 2
GPS

glial limiting end-foot
vascular endothelial growth factor production
cerebral cortex regionalization
seminiferous tubule development
negative regulation of neuron migration
layer formation in cerebral cortex
telencephalon regionalization
protein kinase C signaling
telencephalon glial cell migration
cerebral cortex radial glia guided migration
forebrain regionalization
extracellular matrix binding
cerebral cortex radially oriented cell migration
positive regulation of Rho protein signal transduction
glial cell migration
regulation of neuron migration
cerebral cortex cell migration
positive regulation of neural precursor cell proliferation
telencephalon cell migration
forebrain cell migration
positive regulation of Ras protein signal transduction
collagen binding
positive regulation of small GTPase mediated signal transduction
Rho protein signal transduction
regulation of neural precursor cell proliferation
cerebral cortex development
adenylate cyclase-activating G protein-coupled receptor signaling pathway
male gonad development
development of primary male sexual characteristics
regulation of Rho protein signal transduction
cAMP-mediated signaling
cytokine production
male sex differentiation
heparin binding
cyclic-nucleotide-mediated signaling
pallium development
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
gonad development
gliogenesis
development of primary sexual characteristics