GPR65 [The Human Chemical-Genetic Interaction Map Project]

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======= GPR65 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GPR65
  * **<color #00a2e8>Official Name</color>**: G protein-coupled receptor 65
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8477|8477]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYL9|Q8IYL9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GPR65&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GPR65|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity). {ECO:0000250|UniProtKB:Q61038, ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:27287411}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to acidic pH|
|positive regulation of Rho protein signal transduction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|response to pH|
|positive regulation of stress fiber assembly|
|positive regulation of actin filament bundle assembly|
|positive regulation of Ras protein signal transduction|
|actin cytoskeleton reorganization|
|positive regulation of small GTPase mediated signal transduction|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|activation of GTPase activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of Rho protein signal transduction|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|positive regulation of supramolecular fiber organization|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of cytoskeleton organization|
|regulation of Ras protein signal transduction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of actin filament organization|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cellular metal ion homeostasis|
|actin filament-based process|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular homeostasis|
|apoptotic process|
|regulation of cellular component biogenesis|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GPR65 Expression in NALM6 Cells: 1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>