GPR65

Gene Information

Official Symbol: GPR65
Official Name: G protein-coupled receptor 65
Aliases and Previous Symbols: N/A
Entrez ID: 8477
UniProt: Q8IYL9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411). May have a role in activation-induced cell death or differentiation of T-cells (By similarity). {ECO:0000250|UniProtKB:Q61038, ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:27287411}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18954
Expression level (log2 read counts): 1.19

Expression Distribution

response to acidic pH
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
response to pH
positive regulation of stress fiber assembly
positive regulation of actin filament bundle assembly
positive regulation of Ras protein signal transduction
actin cytoskeleton reorganization
positive regulation of small GTPase mediated signal transduction
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of actin filament bundle assembly
phospholipase C-activating G protein-coupled receptor signaling pathway
activation of GTPase activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of Rho protein signal transduction
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
positive regulation of supramolecular fiber organization
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
positive regulation of cytoskeleton organization
regulation of Ras protein signal transduction
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of actin filament organization
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
regulation of actin cytoskeleton organization
regulation of small GTPase mediated signal transduction
regulation of supramolecular fiber organization
regulation of actin filament-based process
positive regulation of GTPase activity
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
regulation of GTPase activity
divalent inorganic cation homeostasis
actin cytoskeleton organization
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization