GPR88

Entrez Summary: The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017].
UniProt Summary: Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. {ECO:0000250|UniProtKB:Q9EPB7, ECO:0000250|UniProtKB:Q9ESP4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

motor learning
G protein-coupled photoreceptor activity
neuronal action potential
phototransduction
motor activity
detection of visible light
neuromuscular process controlling balance
transmission of nerve impulse
detection of light stimulus
action potential
neuromuscular process
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
multicellular organismal signaling
learning
cellular response to radiation
locomotory behavior
cilium
learning or memory
cognition
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
regulation of membrane potential
response to radiation
cellular component
behavior
detection of stimulus
response to abiotic stimulus
G protein-coupled receptor signaling pathway
nervous system process
integral component of plasma membrane
system process