GPRC5B
Gene Information
- Official Symbol: GPRC5B
- Official Name: G protein-coupled receptor class C group 5 member B
- Aliases and Previous Symbols: N/A
- Entrez ID: 51704
- UniProt: Q9NZH0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Pfam Domains GO Terms
Pfam Domains
| 7tm 3 |
GO Terms
| positive regulation of macrophage cytokine production |
| regulation of macrophage cytokine production |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| protein kinase activator activity |
| positive regulation of cytokine production involved in immune response |
| positive regulation of protein tyrosine kinase activity |
| G protein-coupled receptor binding |
| regulation of cytokine production involved in immune response |
| regulation of protein tyrosine kinase activity |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of inflammatory response |
| regulation of production of molecular mediator of immune response |
| cytoplasmic vesicle membrane |
| positive regulation of canonical Wnt signaling pathway |
| positive regulation of Wnt signaling pathway |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of peptidyl-tyrosine phosphorylation |
| receptor complex |
| positive regulation of immune effector process |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of peptidyl-tyrosine phosphorylation |
| regulation of canonical Wnt signaling pathway |
| activation of protein kinase activity |
| regulation of inflammatory response |
| regulation of Wnt signaling pathway |
| positive regulation of neuron differentiation |
| positive regulation of cytokine production |
| protein kinase binding |
| regulation of immune effector process |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of kinase activity |
| positive regulation of response to external stimulus |
| cell surface |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| intracellular membrane-bounded organelle |
| regulation of cytokine production |
| G protein-coupled receptor activity |
| regulation of defense response |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| nucleolus |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CI-1040 9.5μM R08 exp472 | -2.15 |
| Vemurafenib 6.6μM R08 exp434 | -1.78 |
| SGC2043 10μM R03 exp152 | 1.72 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.457 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5078
- Expression level (log2 read counts): 1.03
Expression Distribution
GPRC5B Expression in NALM6 Cells: 1.03
