GRIK5

Gene Information

Official Symbol: GRIK5
Official Name: glutamate ionotropic receptor kainate type subunit 5
Aliases and Previous Symbols: N/A
Entrez ID: 2901
UniProt: Q16478
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate » AMPA » NMDA = 1S,3R-ACPD.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3508
Expression level (log2 read counts): 0.41

Expression Distribution

SBP bac 3
ANF receptor
Lig chan-Glu bd
Lig chan

kainate selective glutamate receptor activity
kainate selective glutamate receptor complex
protein retention in ER lumen
regulation of synaptic vesicle fusion to presynaptic active zone membrane
maintenance of protein localization in endoplasmic reticulum
glutamate receptor activity
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of vesicle fusion
hippocampal mossy fiber to CA3 synapse
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
maintenance of protein localization in organelle
glutamate receptor signaling pathway
receptor clustering
terminal bouton
integral component of postsynaptic density membrane
positive regulation of neuron apoptotic process
integral component of presynaptic membrane
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
cellular response to glucose stimulus
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
presynaptic membrane
maintenance of protein location in cell
regulation of synaptic vesicle exocytosis
cellular response to carbohydrate stimulus
localization within membrane
PDZ domain binding
cellular glucose homeostasis
positive regulation of neuron death
maintenance of location in cell
regulation of postsynaptic membrane potential
regulation of neurotransmitter secretion
maintenance of protein location
regulation of synaptic vesicle cycle
SH3 domain binding
perikaryon
protein localization to endoplasmic reticulum
response to glucose