GRIPAP1

Gene Information

Official Symbol: GRIPAP1
Official Name: GRIP1 associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 56850
UniProt: Q4V328
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7731
Expression level (log2 read counts): 6.14

Expression Distribution

Screen	Score
Epigallocatechin gallate 20μM R05 exp230	-1.8
LB-100 4.1μM R02 exp72	-1.77

regulation of recycling endosome localization within postsynapse
extrinsic component of postsynaptic early endosome membrane
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
regulation of endosome to plasma membrane protein transport
postsynaptic recycling endosome
neurotransmitter receptor transport, endosome to postsynaptic membrane
neurotransmitter receptor transport, endosome to plasma membrane
endosome to plasma membrane protein transport
regulation of modification of synaptic structure
neurotransmitter receptor transport to postsynaptic membrane
neurotransmitter receptor transport to plasma membrane
regulation of receptor localization to synapse
establishment of protein localization to postsynaptic membrane
regulation of synaptic vesicle recycling
regulation of protein localization to synapse
retrograde transport, endosome to plasma membrane
protein localization to postsynaptic membrane
neurotransmitter receptor transport
receptor localization to synapse
regulation of postsynaptic membrane neurotransmitter receptor levels
establishment of protein localization to plasma membrane
protein localization to synapse
recycling endosome membrane
vesicle-mediated transport to the plasma membrane
regulation of protein localization to plasma membrane
regulation of synaptic vesicle cycle
regulation of protein localization to cell periphery
blood microparticle
protein localization to plasma membrane
regulation of protein localization to membrane
regulation of synapse organization
regulation of synapse structure or activity
protein localization to cell periphery
endosomal transport
regulation of intracellular protein transport
protein-containing complex localization
establishment of protein localization to membrane
axon
glutamatergic synapse
regulation of intracellular transport