GRK1

Entrez Summary: N/A
UniProt Summary: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269|PubMed:15946941}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

rhodopsin kinase activity
G protein-coupled receptor kinase activity
rhodopsin mediated signaling pathway
phototransduction, visible light
photoreceptor disc membrane
regulation of rhodopsin mediated signaling pathway
phototransduction
detection of visible light
detection of light stimulus
cellular response to light stimulus
detection of external stimulus
detection of abiotic stimulus
regulation of G protein-coupled receptor signaling pathway
cellular response to radiation
protein autophosphorylation
visual perception
sensory perception of light stimulus
protein kinase activity
response to light stimulus
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to radiation
detection of stimulus
sensory perception
protein phosphorylation
regulation of response to external stimulus
response to abiotic stimulus
phosphorylation
G protein-coupled receptor signaling pathway
nervous system process
ATP binding
system process