GRK4

Entrez Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

rhodopsin kinase activity
G protein-coupled receptor kinase activity
G protein-coupled receptor internalization
desensitization of G protein-coupled receptor signaling pathway
negative adaptation of signaling pathway
adaptation of signaling pathway
photoreceptor disc membrane
regulation of rhodopsin mediated signaling pathway
negative regulation of G protein-coupled receptor signaling pathway
receptor internalization
receptor metabolic process
cell cortex
regulation of G protein-coupled receptor signaling pathway
receptor-mediated endocytosis
neuronal cell body
dendrite
endocytosis
import into cell
protein phosphorylation
regulation of response to external stimulus
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ATP binding
negative regulation of response to stimulus
vesicle-mediated transport