GRM2

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7620613}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

group II metabotropic glutamate receptor activity
glutamate homeostasis
amino acid homeostasis
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
G protein-coupled glutamate receptor signaling pathway
glutamate receptor activity
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
negative regulation of lyase activity
regulation of adenylate cyclase activity
glutamate secretion
calcium channel regulator activity
regulation of cyclase activity
integral component of postsynaptic membrane
regulation of lyase activity
glutamate receptor signaling pathway
acidic amino acid transport
anion homeostasis
regulation of synaptic transmission, glutamatergic
presynaptic membrane
dicarboxylic acid transport
acid secretion
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
amino acid transport
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
organic acid transport
carboxylic acid transport
axon
chemical synaptic transmission
anterograde trans-synaptic signaling
dendrite
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
organic anion transport
synaptic signaling
cell junction
anion transport
G protein-coupled receptor activity