GRM3

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

group II metabotropic glutamate receptor activity
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
G protein-coupled glutamate receptor signaling pathway
glutamate receptor activity
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
negative regulation of lyase activity
regulation of adenylate cyclase activity
calcium channel regulator activity
regulation of cyclase activity
glutamate receptor signaling pathway
regulation of lyase activity
integral component of postsynaptic membrane
integral component of presynaptic membrane
regulation of synaptic transmission, glutamatergic
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
dendritic spine
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
postsynaptic density
axon
glutamatergic synapse
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
G protein-coupled receptor activity
negative regulation of catalytic activity
cell-cell signaling
negative regulation of molecular function
G protein-coupled receptor signaling pathway
integral component of plasma membrane