GRN
Gene Information
- Official Symbol: GRN
- Official Name: granulin precursor
- Aliases and Previous Symbols: N/A
- Entrez ID: 2896
- UniProt: P28799
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Granulin |
GO Terms
| positive regulation of lysosome organization |
| positive regulation of inflammatory response to wounding |
| positive regulation of protein folding |
| microglial cell activation involved in immune response |
| regulation of inflammatory response to wounding |
| astrocyte activation involved in immune response |
| negative regulation of respiratory burst involved in inflammatory response |
| negative regulation of neutrophil activation |
| regulation of lysosome organization |
| negative regulation of respiratory burst |
| regulation of respiratory burst involved in inflammatory response |
| negative regulation of microglial cell activation |
| lysosomal lumen acidification |
| positive regulation of aspartic-type peptidase activity |
| positive regulation of axon regeneration |
| positive regulation of neuron projection regeneration |
| regulation of protein folding |
| positive regulation of defense response to bacterium |
| regulation of aspartic-type peptidase activity |
| regulation of neutrophil activation |
| regulation of lysosomal lumen pH |
| negative regulation of neuroinflammatory response |
| macrophage activation involved in immune response |
| positive regulation of vacuole organization |
| negative regulation of macrophage activation |
| regulation of microglial cell activation |
| regulation of respiratory burst |
| regulation of defense response to bacterium |
| astrocyte activation |
| vacuolar acidification |
| regulation of axon regeneration |
| regulation of neuron projection regeneration |
| leukocyte activation involved in inflammatory response |
| microglial cell activation |
| regulation of neuroinflammatory response |
| astrocyte development |
| glial cell activation |
| neuroinflammatory response |
| regulation of vacuole organization |
| intracellular pH reduction |
| pH reduction |
| macrophage activation |
| regulation of macrophage activation |
| astrocyte differentiation |
| positive regulation of neuron apoptotic process |
| negative regulation of innate immune response |
| lysosome organization |
| lytic vacuole organization |
| positive regulation of response to wounding |
| regulation of intracellular pH |
| azurophil granule lumen |
| regulation of cellular pH |
| positive regulation of neuron death |
| negative regulation of response to biotic stimulus |
| regulation of pH |
| positive regulation of endothelial cell migration |
| chaperone binding |
| lysosomal transport |
| glial cell development |
| cellular monovalent inorganic cation homeostasis |
| negative regulation of immune effector process |
| late endosome |
| vacuole organization |
| negative regulation of inflammatory response |
| positive regulation of inflammatory response |
| monovalent inorganic cation homeostasis |
| positive regulation of epithelial cell migration |
| vacuolar transport |
| negative regulation of neuron apoptotic process |
| negative regulation of immune response |
| regulation of endothelial cell migration |
| positive regulation of angiogenesis |
| growth factor activity |
| regulation of response to wounding |
| trans-Golgi network |
| glial cell differentiation |
| cytokine activity |
| negative regulation of leukocyte activation |
| protein stabilization |
| positive regulation of vasculature development |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidase activity |
| negative regulation of cell activation |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| negative regulation of defense response |
| gliogenesis |
| negative regulation of multi-organism process |
| regulation of epithelial cell migration |
| lysosome |
| endosome |
| positive regulation of neuron projection development |
| regulation of angiogenesis |
| regulation of protein stability |
| lysosomal membrane |
| regulation of neuron death |
| regulation of vasculature development |
| regulation of epithelial cell proliferation |
| regulation of inflammatory response |
| positive regulation of proteolysis |
| positive regulation of response to biotic stimulus |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| negative regulation of immune system process |
| regulation of peptidase activity |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of neurogenesis |
| positive regulation of defense response |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of neuron projection development |
| inflammatory response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| regulation of response to biotic stimulus |
| myeloid cell activation involved in immune response |
| positive regulation of cell motility |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of locomotion |
| myeloid leukocyte activation |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| cellular cation homeostasis |
| regulation of cell activation |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| regulated exocytosis |
| cation homeostasis |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| regulation of defense response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| ion homeostasis |
| exocytosis |
| regulation of neurogenesis |
| regulation of cell migration |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| Golgi apparatus |
| regulation of cellular component movement |
| negative regulation of cell death |
| secretion by cell |
| endoplasmic reticulum |
| export from cell |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| chemical homeostasis |
| secretion |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| regulation of organelle organization |
| defense response |
| positive regulation of developmental process |
| RNA binding |
| positive regulation of catalytic activity |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| regulation of programmed cell death |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7673
- Expression level (log2 read counts): 7.48
Expression Distribution
GRN Expression in NALM6 Cells: 7.48
