GSTM2

Gene Information

Official Symbol: GSTM2
Official Name: glutathione S-transferase mu 2
Aliases and Previous Symbols: N/A
Entrez ID: 2946
UniProt: P28161
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:16549767}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8978
Expression level (log2 read counts): 4.62

Expression Distribution

GST N
GST C

cellular detoxification of nitrogen compound
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
nitrobenzene metabolic process
regulation of skeletal muscle contraction by calcium ion signaling
detoxification of nitrogen compound
positive regulation of ryanodine-sensitive calcium-release channel activity
cellular response to caffeine
glutathione binding
negative regulation of ryanodine-sensitive calcium-release channel activity
regulation of skeletal muscle contraction
cellular response to purine-containing compound
xenobiotic catabolic process
relaxation of cardiac muscle
negative regulation of release of sequestered calcium ion into cytosol
positive regulation of sequestering of calcium ion
linoleic acid metabolic process
response to diuretic
response to caffeine
negative regulation of calcium ion transport into cytosol
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
glutathione peroxidase activity
relaxation of muscle
glutathione derivative metabolic process
glutathione derivative biosynthetic process
regulation of cardiac muscle contraction by calcium ion signaling
benzene-containing compound metabolic process
regulation of ryanodine-sensitive calcium-release channel activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
glutathione transferase activity
negative regulation of calcium-mediated signaling
cellular response to alkaloid
negative regulation of calcium ion transmembrane transporter activity
positive regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion transmembrane transport
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of calcium-mediated signaling
negative regulation of cation channel activity
sarcoplasmic reticulum
positive regulation of calcium ion transport into cytosol
glutathione metabolic process