GSTM3

Entrez Summary: N/A
UniProt Summary: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|PubMed:10587441}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 1 to 2μM on day4 R04 exp164	-2.23
Pimelic-diphenylamide-106 5μM R00 exp28	-2.06
Clomiphene 4.4μM R02 exp68	-2.04
MK2206 4μM R08 exp504	-1.8
Pifithrin-alpha 20μM R07 exp390	-1.78
5-Fluorouracil 20μM R00 exp2	1.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GST N
GST C

cellular detoxification of nitrogen compound
establishment of blood-nerve barrier
nitrobenzene metabolic process
detoxification of nitrogen compound
sperm fibrous sheath
glutathione binding
xenobiotic catabolic process
glutathione derivative metabolic process
glutathione derivative biosynthetic process
benzene-containing compound metabolic process
glutathione transferase activity
endothelial cell development
glutathione metabolic process
intercellular bridge
peripheral nervous system development
response to estrogen
endothelial cell differentiation
endothelium development
cellular detoxification
detoxification
xenobiotic metabolic process
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
epithelial cell development
cellular modified amino acid metabolic process
cellular response to toxic substance
response to xenobiotic stimulus
enzyme binding
sulfur compound metabolic process
cofactor metabolic process
response to toxic substance
peptide metabolic process
epithelial cell differentiation
cellular amide metabolic process
protein homodimerization activity
identical protein binding
response to nitrogen compound
epithelium development
organonitrogen compound biosynthetic process
cell development