GTF2B [The Human Chemical-Genetic Interaction Map Project]

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======= GTF2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GTF2B
  * **<color #00a2e8>Official Name</color>**: general transcription factor IIB
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2959|2959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00403|Q00403]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GTF2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GTF2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189963|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIIB|
|TF Zn Ribbon|
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA-templated transcriptional start site selection|
|RNA polymerase II core complex assembly|
|transcriptional start site selection at RNA polymerase II promoter|
|RNA polymerase II complex recruiting activity|
|positive regulation of core promoter binding|
|transcriptional preinitiation complex|
|regulation of core promoter binding|
|core promoter binding|
|RNA polymerase II preinitiation complex assembly|
|RNA polymerase II general transcription initiation factor activity|
|positive regulation by host of viral transcription|
|acetyltransferase activity|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|TBP-class protein binding|
|positive regulation of transcription regulatory region DNA binding|
|positive regulation of DNA-templated transcription, initiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|transcription preinitiation complex assembly|
|thyroid hormone receptor binding|
|RNA polymerase II complex binding|
|RNA polymerase II core promoter sequence-specific DNA binding|
|regulation of DNA-templated transcription, initiation|
|transcription factor TFIID complex|
|positive regulation of viral transcription|
|protein-DNA complex|
|promoter-specific chromatin binding|
|histone acetyltransferase activity|
|regulation of transcription regulatory region DNA binding|
|positive regulation of DNA binding|
|regulation of viral transcription|
|snRNA transcription by RNA polymerase II|
|modification by host of symbiont morphology or physiology|
|snRNA transcription|
|RNA polymerase II transcription factor complex|
|interaction with symbiont|
|ncRNA transcription|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|chromosome|
|internal protein amino acid acetylation|
|regulation of DNA binding|
|protein acetylation|
|modification of morphology or physiology of other organism|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of binding|
|protein acylation|
|protein-DNA complex assembly|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein-DNA complex subunit organization|
|nuclear body|
|peptidyl-lysine modification|
|transcription factor binding|
|histone modification|
|covalent chromatin modification|
|regulation of binding|
|transcription by RNA polymerase II|
|positive regulation of multi-organism process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|viral process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.27|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.9|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.81|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.75|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.72|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 712/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/25|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 424
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GTF2B Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>