GTF2B
Gene Information
- Official Symbol: GTF2B
- Official Name: general transcription factor IIB
- Aliases and Previous Symbols: N/A
- Entrez ID: 2959
- UniProt: Q00403
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.
Pfam Domains GO Terms
Pfam Domains
| TFIIB |
| TF Zn Ribbon |
| Cyclin N |
GO Terms
| DNA-templated transcriptional start site selection |
| RNA polymerase II core complex assembly |
| transcriptional start site selection at RNA polymerase II promoter |
| RNA polymerase II complex recruiting activity |
| positive regulation of core promoter binding |
| transcriptional preinitiation complex |
| regulation of core promoter binding |
| core promoter binding |
| RNA polymerase II preinitiation complex assembly |
| RNA polymerase II general transcription initiation factor activity |
| positive regulation by host of viral transcription |
| acetyltransferase activity |
| positive regulation of transcription initiation from RNA polymerase II promoter |
| TBP-class protein binding |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of DNA-templated transcription, initiation |
| regulation of transcription initiation from RNA polymerase II promoter |
| transcription preinitiation complex assembly |
| thyroid hormone receptor binding |
| RNA polymerase II complex binding |
| RNA polymerase II core promoter sequence-specific DNA binding |
| regulation of DNA-templated transcription, initiation |
| transcription factor TFIID complex |
| positive regulation of viral transcription |
| protein-DNA complex |
| promoter-specific chromatin binding |
| histone acetyltransferase activity |
| regulation of transcription regulatory region DNA binding |
| positive regulation of DNA binding |
| regulation of viral transcription |
| snRNA transcription by RNA polymerase II |
| modification by host of symbiont morphology or physiology |
| snRNA transcription |
| RNA polymerase II transcription factor complex |
| interaction with symbiont |
| ncRNA transcription |
| positive regulation of viral process |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| histone acetylation |
| internal peptidyl-lysine acetylation |
| peptidyl-lysine acetylation |
| chromosome |
| internal protein amino acid acetylation |
| regulation of DNA binding |
| protein acetylation |
| modification of morphology or physiology of other organism |
| transcription initiation from RNA polymerase II promoter |
| positive regulation of binding |
| protein acylation |
| protein-DNA complex assembly |
| regulation of viral process |
| DNA-templated transcription, initiation |
| regulation of symbiosis, encompassing mutualism through parasitism |
| protein-DNA complex subunit organization |
| nuclear body |
| peptidyl-lysine modification |
| transcription factor binding |
| histone modification |
| covalent chromatin modification |
| regulation of binding |
| transcription by RNA polymerase II |
| positive regulation of multi-organism process |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| chromatin organization |
| viral process |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| zinc ion binding |
| cellular protein-containing complex assembly |
| peptidyl-amino acid modification |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Benzoate 20000μM R08 exp456 | -2.27 |
| MK2206 4μM R08 exp504 | -1.9 |
| Chloroquine 32μM R08 exp470 | -1.81 |
| Trametinib 10μM R02 exp83 | -1.75 |
| Palbociclib 1μM R07 exp382 | -1.72 |
| Brefeldin A 0.02μM R00 exp8 | 2.01 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 712/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 27/28 |
| bone | 25/25 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/15 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 73/75 |
| lymphocyte | 14/14 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 7/7 |
| thyroid | 2/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 424
- Expression level (log2 read counts): 4.89
Expression Distribution
GTF2B Expression in NALM6 Cells: 4.89
