GTF2E1

Entrez Summary: N/A
UniProt Summary: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 568/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	23/28
bone	20/25
breast	25/33
central nervous system	47/56
cervix	3/4
colorectal	13/17
esophagus	12/13
fibroblast	1/1
gastric	10/15
kidney	13/21
liver	18/20
lung	60/75
lymphocyte	12/14
ovary	21/26
pancreas	21/24
peripheral nervous system	10/16
plasma cell	13/15
prostate	1/1
skin	20/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	11/22
urinary tract	17/29
uterus	4/5

Expression Distribution

transcriptional open complex formation at RNA polymerase II promoter
protein-DNA complex remodeling
DNA-templated transcriptional open complex formation
transcription factor TFIIE complex
TFIIH-class transcription factor complex binding
transcriptional preinitiation complex
RNA polymerase II general transcription initiation factor activity
protein-containing complex remodeling
RNA polymerase II complex binding
transcription factor TFIID complex
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
protein-DNA complex subunit organization
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
viral process
symbiotic process
interspecies interaction between organisms
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression