GYPC
Gene Information
- Official Symbol: GYPC
- Official Name: glycophorin C (Gerbich blood group)
- Aliases and Previous Symbols: N/A
- Entrez ID: 2995
- UniProt: P04921
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]. Sequence Note: This RefSeq record represents the GYPC*001.1.1 allele.
- UniProt Summary: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5153
- Expression level (log2 read counts): 3.53
GYPC Expression in NALM6 Cells: 3.53
