H1FNT

Entrez Summary: N/A
UniProt Summary: Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1. {ECO:0000250|UniProtKB:Q8CJI4, ECO:0000269|PubMed:16533358}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

spermatid nucleus elongation
sperm chromatin condensation
nucleosome positioning
negative regulation of chromatin silencing
spermatid nucleus differentiation
nuclear euchromatin
negative regulation of gene silencing
regulation of chromatin silencing
chromosome condensation
nucleosomal DNA binding
negative regulation of DNA recombination
negative regulation of chromatin organization
positive regulation of gene expression, epigenetic
double-stranded DNA binding
regulation of DNA recombination
negative regulation of DNA metabolic process
regulation of gene silencing
nucleus organization
negative regulation of chromosome organization
chromatin assembly
spermatid development
chromatin assembly or disassembly
spermatid differentiation
nucleosome organization
DNA packaging
regulation of chromatin organization
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
germ cell development
DNA conformation change
regulation of chromosome organization
cellular process involved in reproduction in multicellular organism
regulation of DNA metabolic process
negative regulation of organelle organization
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
chromatin organization