H1FOO [The Human Chemical-Genetic Interaction Map Project]

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======= H1FOO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: H1-8
  * **<color #00a2e8>Official Name</color>**: H1.8 linker histone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=132243|132243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZA3|Q8IZA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=H1FOO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20H1FOO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Linker histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleosome positioning|
|negative regulation of chromatin silencing|
|negative regulation of stem cell differentiation|
|regulation of DNA methylation|
|negative regulation of gene silencing|
|regulation of chromatin silencing|
|chromosome condensation|
|nucleosomal DNA binding|
|negative regulation of DNA recombination|
|negative regulation of chromatin organization|
|positive regulation of gene expression, epigenetic|
|nucleosome|
|double-stranded DNA binding|
|regulation of DNA recombination|
|nucleosome assembly|
|regulation of stem cell differentiation|
|negative regulation of DNA metabolic process|
|regulation of gene silencing|
|chromatin assembly|
|negative regulation of chromosome organization|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|meiotic cell cycle|
|regulation of gene expression, epigenetic|
|protein-DNA complex subunit organization|
|DNA conformation change|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|chromatin organization|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|cellular protein-containing complex assembly|
|nucleolus|
|negative regulation of developmental process|
|chromosome organization|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7199
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='H1FOO Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>