H1FOO

Entrez Summary: N/A
UniProt Summary: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome positioning
negative regulation of chromatin silencing
negative regulation of stem cell differentiation
regulation of DNA methylation
negative regulation of gene silencing
regulation of chromatin silencing
chromosome condensation
nucleosomal DNA binding
negative regulation of DNA recombination
negative regulation of chromatin organization
positive regulation of gene expression, epigenetic
nucleosome
double-stranded DNA binding
regulation of DNA recombination
nucleosome assembly
regulation of stem cell differentiation
negative regulation of DNA metabolic process
regulation of gene silencing
chromatin assembly
negative regulation of chromosome organization
chromatin assembly or disassembly
nucleosome organization
DNA packaging
regulation of chromatin organization
protein-DNA complex assembly
meiotic cell cycle
regulation of gene expression, epigenetic
protein-DNA complex subunit organization
DNA conformation change
regulation of chromosome organization
regulation of DNA metabolic process
negative regulation of organelle organization
chromatin organization
negative regulation of cellular component organization
negative regulation of cell differentiation
cellular protein-containing complex assembly
nucleolus
negative regulation of developmental process
chromosome organization
regulation of organelle organization