H6PD

Entrez Summary: There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008].
UniProt Summary: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glucose 1-dehydrogenase [NAD(P)] activity
glucose-6-phosphate dehydrogenase activity
6-phosphogluconolactonase activity
pentose-phosphate shunt
NADPH regeneration
glucose 6-phosphate metabolic process
NADP metabolic process
NADP binding
glucose metabolic process
hexose metabolic process
monosaccharide metabolic process
endoplasmic reticulum lumen
generation of precursor metabolites and energy
carbohydrate metabolic process
organophosphate metabolic process
oxidation-reduction process
carbohydrate derivative metabolic process
small molecule metabolic process