HAGH

Entrez Summary: The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
UniProt Summary: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

methylglyoxal catabolic process to lactate
hydroxyacylglutathione hydrolase activity
methylglyoxal catabolic process
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
methylglyoxal metabolic process
ketone catabolic process
aldehyde catabolic process
lactate metabolic process
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
cellular modified amino acid biosynthetic process
cellular aldehyde metabolic process
glutathione metabolic process
pyruvate metabolic process
cellular ketone metabolic process
sulfur compound biosynthetic process
cellular modified amino acid metabolic process
cofactor biosynthetic process
sulfur compound metabolic process
mitochondrial matrix
peptide biosynthetic process
small molecule catabolic process
cofactor metabolic process
organic hydroxy compound metabolic process
amide biosynthetic process
peptide metabolic process
monocarboxylic acid metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process