HAND1 [The Human Chemical-Genetic Interaction Map Project]

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======= HAND1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAND1
  * **<color #00a2e8>Official Name</color>**: heart and neural crest derivatives expressed 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9421|9421]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96004|O96004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAND1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAND1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602406|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic heart tube formation|
|cardiac left ventricle formation|
|cardiac right ventricle formation|
|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|cardiac ventricle formation|
|cardiac chamber formation|
|trophoblast giant cell differentiation|
|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|
|cardiac left ventricle morphogenesis|
|trophectodermal cell differentiation|
|cardiac right ventricle morphogenesis|
|negative regulation of transcription regulatory region DNA binding|
|bHLH transcription factor binding|
|cell differentiation involved in embryonic placenta development|
|cartilage morphogenesis|
|blastocyst formation|
|ventricular cardiac muscle tissue morphogenesis|
|regulation of transcription regulatory region DNA binding|
|ventricular cardiac muscle tissue development|
|negative regulation of DNA binding|
|heart looping|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|mesoderm formation|
|cardiac muscle tissue morphogenesis|
|mesoderm morphogenesis|
|RNA polymerase II transcription factor complex|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|embryonic heart tube development|
|muscle tissue morphogenesis|
|odontogenesis of dentin-containing tooth|
|embryonic placenta development|
|muscle organ morphogenesis|
|blastocyst development|
|cardiac septum development|
|formation of primary germ layer|
|determination of left/right symmetry|
|odontogenesis|
|embryonic epithelial tube formation|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|regulation of DNA binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|gastrulation|
|negative regulation of DNA-binding transcription factor activity|
|cardiac muscle tissue development|
|negative regulation of binding|
|cardiac chamber development|
|cartilage development|
|transcription regulatory region DNA binding|
|mesenchyme development|
|connective tissue development|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|heart morphogenesis|
|striated muscle tissue development|
|transcription coactivator activity|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|angiogenesis|
|transcription factor binding|
|enzyme binding|
|regulation of binding|
|in utero embryonic development|
|blood vessel morphogenesis|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|muscle structure development|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8965
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAND1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>