HAND1

Entrez Summary: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

embryonic heart tube formation
cardiac left ventricle formation
cardiac right ventricle formation
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
cardiac ventricle formation
cardiac chamber formation
trophoblast giant cell differentiation
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
cardiac left ventricle morphogenesis
trophectodermal cell differentiation
cardiac right ventricle morphogenesis
negative regulation of transcription regulatory region DNA binding
bHLH transcription factor binding
cell differentiation involved in embryonic placenta development
cartilage morphogenesis
blastocyst formation
ventricular cardiac muscle tissue morphogenesis
regulation of transcription regulatory region DNA binding
ventricular cardiac muscle tissue development
negative regulation of DNA binding
heart looping
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
mesoderm formation
cardiac muscle tissue morphogenesis
mesoderm morphogenesis
RNA polymerase II transcription factor complex
cardiac septum morphogenesis
cardiac ventricle morphogenesis
embryonic heart tube development
muscle tissue morphogenesis
odontogenesis of dentin-containing tooth
embryonic placenta development
muscle organ morphogenesis
blastocyst development
cardiac septum development
formation of primary germ layer
determination of left/right symmetry
odontogenesis
embryonic epithelial tube formation