HAO2

Entrez Summary: This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IMPDH
FMN dh

medium-chain-(S)-2-hydroxy-acid oxidase activity
very-long-chain-(S)-2-hydroxy-acid oxidase activity
long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
(S)-2-hydroxy-acid oxidase activity
FMN binding
peroxisomal matrix
establishment of protein localization to peroxisome
protein localization to peroxisome
protein targeting to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
cellular lipid catabolic process
lipid modification
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
monocarboxylic acid metabolic process
protein localization to organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
intracellular protein transport
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization