HARS [The Human Chemical-Genetic Interaction Map Project]

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======= HARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HARS1
  * **<color #00a2e8>Official Name</color>**: histidyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3035|3035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12081|P12081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142810|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance. {ECO:0000269|PubMed:26072516, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2b|
|WHEP-TRS|
|HGTP anticodon2|
|HGTP anticodon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histidyl-tRNA aminoacylation|
|histidine-tRNA ligase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.82|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.18|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.07|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.97|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.95|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.87|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.82|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.76|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.73|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.96|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.96|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.97|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.34|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.9|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cep350|CEP350]]|0.776|
|[[:human genes:p:pmpcb|PMPCB]]|0.745|
|[[:human genes:m:meaf6|MEAF6]]|0.741|
|[[:human genes:z:znf608|ZNF608]]|0.722|
|[[:human genes:n:nars|NARS]]|0.718|
|[[:human genes:c:cct7|CCT7]]|0.71|
|[[:human genes:p:pisd|PISD]]|0.696|
|[[:human genes:g:gemin5|GEMIN5]]|0.696|
|[[:human genes:m:mars|MARS]]|0.691|
|[[:human genes:c:cct5|CCT5]]|0.684|
|[[:human genes:n:nsmce1|NSMCE1]]|0.683|
|[[:human genes:t:tgs1|TGS1]]|0.674|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.67|
|[[:human genes:k:kars|KARS]]|0.664|
|[[:human genes:g:grpel1|GRPEL1]]|0.662|
|[[:human genes:g:gabpa|GABPA]]|0.659|
|[[:human genes:e:eif4e|EIF4E]]|0.659|
|[[:human genes:h:hspd1|HSPD1]]|0.659|
|[[:human genes:t:tle4|TLE4]]|0.657|
|[[:human genes:p:pelo|PELO]]|0.652|
|[[:human genes:g:gabpb1|GABPB1]]|0.651|
|[[:human genes:r:rptor|RPTOR]]|0.649|
|[[:human genes:e:eif2b3|EIF2B3]]|0.648|
|[[:human genes:t:tsr2|TSR2]]|0.647|
|[[:human genes:m:mtor|MTOR]]|0.645|
|[[:human genes:c:cars|CARS]]|0.642|
|[[:human genes:d:dars|DARS]]|0.641|
|[[:human genes:e:eif3f|EIF3F]]|0.639|
|[[:human genes:c:cdc123|CDC123]]|0.638|
|[[:human genes:z:znf259|ZNF259]]|0.638|
|[[:human genes:u:ube2k|UBE2K]]|0.635|
|[[:human genes:a:apaf1|APAF1]]|0.635|
|[[:human genes:p:plaa|PLAA]]|0.629|
|[[:human genes:h:hccs|HCCS]]|0.628|
|[[:human genes:t:tbce|TBCE]]|0.625|
|[[:human genes:g:gmppb|GMPPB]]|0.624|
|[[:human genes:e:eny2|ENY2]]|0.622|
|[[:human genes:p:prelid1|PRELID1]]|0.622|
|[[:human genes:n:nxt1|NXT1]]|0.619|
|[[:human genes:t:taz|TAZ]]|0.619|
|[[:human genes:g:gfpt1|GFPT1]]|0.617|
|[[:human genes:i:iars2|IARS2]]|0.616|
|[[:human genes:y:yars|YARS]]|0.613|
|[[:human genes:n:nsmce2|NSMCE2]]|0.61|
|[[:human genes:p:pmm2|PMM2]]|0.607|
|[[:human genes:d:dhps|DHPS]]|0.604|
|[[:human genes:u:usp25|USP25]]|0.602|
|[[:human genes:c:csnk2b|CSNK2B]]|0.6|
|[[:human genes:s:spcs3|SPCS3]]|0.599|
|[[:human genes:i:iars|IARS]]|0.598|
|[[:human genes:t:tcp1|TCP1]]|0.598|
|[[:human genes:i:ing3|ING3]]|0.594|
|[[:human genes:t:tamm41|TAMM41]]|0.594|
|[[:human genes:u:uap1|UAP1]]|0.593|
|[[:human genes:s:suv420h1|SUV420H1]]|0.593|
|[[:human genes:d:diablo|DIABLO]]|0.59|
|[[:human genes:f:foxo1|FOXO1]]|0.587|
|[[:human genes:g:gipc2|GIPC2]]|0.587|
|[[:human genes:t:thoc6|THOC6]]|0.585|
|[[:human genes:d:dpf2|DPF2]]|0.585|
|[[:human genes:n:nudt10|NUDT10]]|0.584|
|[[:human genes:d:dad1|DAD1]]|0.583|
|[[:human genes:u:uhrf1|UHRF1]]|0.582|
|[[:human genes:p:pam16|PAM16]]|0.581|
|[[:human genes:n:nupl2|NUPL2]]|0.58|
|[[:human genes:v:vrk1|VRK1]]|0.579|
|[[:human genes:a:alg11|ALG11]]|0.578|
|[[:human genes:p:pdcd5|PDCD5]]|0.578|
|[[:human genes:d:ddost|DDOST]]|0.577|
|[[:human genes:n:nae1|NAE1]]|0.576|
|[[:human genes:c:cdc20|CDC20]]|0.575|
|[[:human genes:f:farsb|FARSB]]|0.574|
|[[:human genes:s:sik1|SIK1]]|0.573|
|[[:human genes:r:rnmt|RNMT]]|0.573|
|[[:human genes:p:prr5|PRR5]]|0.572|
|[[:human genes:t:tbcd|TBCD]]|0.572|
|[[:human genes:c:cct6a|CCT6A]]|0.571|
|[[:human genes:t:tsen2|TSEN2]]|0.569|
|[[:human genes:a:aars|AARS]]|0.569|
|[[:human genes:s:slc35b1|SLC35B1]]|0.568|
|[[:human genes:p:pcbp2|PCBP2]]|0.567|
|[[:human genes:o:oip5|OIP5]]|0.567|
|[[:human genes:s:seh1l|SEH1L]]|0.567|
|[[:human genes:f:fam210a|FAM210A]]|0.567|
|[[:human genes:f:faf2|FAF2]]|0.565|
|[[:human genes:t:timm44|TIMM44]]|0.564|
|[[:human genes:s:sod2|SOD2]]|0.564|
|[[:human genes:t:ten1|TEN1]]|0.564|
|[[:human genes:s:srp14|SRP14]]|0.564|
|[[:human genes:a:alg5|ALG5]]|0.563|
|[[:human genes:p:phb2|PHB2]]|0.562|
|[[:human genes:d:dhdds|DHDDS]]|0.562|
|[[:human genes:a:alg14|ALG14]]|0.562|
|[[:human genes:b:bcl7a|BCL7A]]|0.561|
|[[:human genes:t:tbca|TBCA]]|0.56|
|[[:human genes:t:tcea3|TCEA3]]|0.558|
|[[:human genes:m:mfn1|MFN1]]|0.557|
|[[:human genes:c:crls1|CRLS1]]|0.557|
|[[:human genes:x:xpo5|XPO5]]|0.556|
|[[:human genes:r:rpe|RPE]]|0.554|
|[[:human genes:c:cycs|CYCS]]|0.553|
|[[:human genes:n:nup50|NUP50]]|0.552|
|[[:human genes:e:eprs|EPRS]]|0.551|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.549|
|[[:human genes:h:hspa9|HSPA9]]|0.547|
|[[:human genes:s:srp72|SRP72]]|0.546|
|[[:human genes:a:alg2|ALG2]]|0.546|
|[[:human genes:t:trappc3|TRAPPC3]]|0.545|
|[[:human genes:o:otud5|OTUD5]]|0.544|
|[[:human genes:o:or6p1|OR6P1]]|0.544|
|[[:human genes:c:ctc1|CTC1]]|0.544|
|[[:human genes:t:tpi1|TPI1]]|0.544|
|[[:human genes:a:actg1|ACTG1]]|0.543|
|[[:human genes:c:chchd4|CHCHD4]]|0.542|
|[[:human genes:t:triap1|TRIAP1]]|0.54|
|[[:human genes:u:usp48|USP48]]|0.54|
|[[:human genes:e:eno1|ENO1]]|0.54|
|[[:human genes:r:rpn1|RPN1]]|0.54|
|[[:human genes:g:gfer|GFER]]|0.539|
|[[:human genes:g:ggps1|GGPS1]]|0.539|
|[[:human genes:h:hhex|HHEX]]|0.538|
|[[:human genes:o:ogt|OGT]]|0.538|
|[[:human genes:t:tma16|TMA16]]|0.537|
|[[:human genes:i:ipo13|IPO13]]|0.537|
|[[:human genes:a:ahcy|AHCY]]|0.537|
|[[:human genes:p:per2|PER2]]|0.536|
|[[:human genes:b:bpifb3|BPIFB3]]|0.536|
|[[:human genes:u:utp23|UTP23]]|0.535|
|[[:human genes:t:thoc7|THOC7]]|0.534|
|[[:human genes:e:eri1|ERI1]]|0.534|
|[[:human genes:s:slc5a10|SLC5A10]]|0.533|
|[[:human genes:u:ube2g1|UBE2G1]]|0.533|
|[[:human genes:h:hmgb2|HMGB2]]|0.532|
|[[:human genes:m:mat1a|MAT1A]]|0.53|
|[[:human genes:d:ddx20|DDX20]]|0.528|
|[[:human genes:t:txnl4b|TXNL4B]]|0.527|
|[[:human genes:r:rtcb|RTCB]]|0.527|
|[[:human genes:t:trmt5|TRMT5]]|0.527|
|[[:human genes:t:tmed9|TMED9]]|0.527|
|[[:human genes:r:rbmx2|RBMX2]]|0.526|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.525|
|[[:human genes:h:hist1h3g|HIST1H3G]]|0.525|
|[[:human genes:a:arl2|ARL2]]|0.523|
|[[:human genes:v:vmp1|VMP1]]|0.523|
|[[:human genes:e:epc2|EPC2]]|0.523|
|[[:human genes:c:c15orf41|C15orf41]]|0.522|
|[[:human genes:u:urod|UROD]]|0.522|
|[[:human genes:b:bub1|BUB1]]|0.519|
|[[:human genes:t:timm13|TIMM13]]|0.517|
|[[:human genes:s:sssca1|SSSCA1]]|0.517|
|[[:human genes:c:cct2|CCT2]]|0.517|
|[[:human genes:r:rabggtb|RABGGTB]]|0.517|
|[[:human genes:e:elf2|ELF2]]|0.515|
|[[:human genes:c:casp9|CASP9]]|0.514|
|[[:human genes:s:smc6|SMC6]]|0.514|
|[[:human genes:n:nudt21|NUDT21]]|0.513|
|[[:human genes:s:spcs2|SPCS2]]|0.513|
|[[:human genes:s:s1pr1|S1PR1]]|0.512|
|[[:human genes:f:fli1|FLI1]]|0.511|
|[[:human genes:m:mab21l3|MAB21L3]]|0.511|
|[[:human genes:c:c8orf46|C8orf46]]|0.511|
|[[:human genes:c:ccdc6|CCDC6]]|0.51|
|[[:human genes:c:cdipt|CDIPT]]|0.509|
|[[:human genes:n:nudt11|NUDT11]]|0.507|
|[[:human genes:t:tsen34|TSEN34]]|0.506|
|[[:human genes:s:stau1|STAU1]]|0.506|
|[[:human genes:t:taf1a|TAF1A]]|0.505|
|[[:human genes:x:xrcc2|XRCC2]]|0.505|
|[[:human genes:c:cdkn1a|CDKN1A]]|0.505|
|[[:human genes:c:c12orf74|C12orf74]]|0.502|
|[[:human genes:r:rad1|RAD1]]|0.502|
|[[:human genes:a:anapc10|ANAPC10]]|0.501|
|[[:human genes:b:bap1|BAP1]]|0.501|
|[[:human genes:t:tut1|TUT1]]|0.5|
|[[:human genes:w:wdr24|WDR24]]|0.499|
|[[:human genes:s:sars|SARS]]|0.497|
|[[:human genes:t:trim28|TRIM28]]|0.497|
|[[:human genes:a:apobec3f|APOBEC3F]]|0.497|
|[[:human genes:t:taf1c|TAF1C]]|0.497|
|[[:human genes:h:haus8|HAUS8]]|0.496|
|[[:human genes:u:uba3|UBA3]]|0.496|
|[[:human genes:k:kdm6b|KDM6B]]|0.496|
|[[:human genes:l:loc100132813|LOC100132813]]|0.495|
|[[:human genes:e:exoc3|EXOC3]]|0.495|
|[[:human genes:p:polr3b|POLR3B]]|0.494|
|[[:human genes:s:srp68|SRP68]]|0.494|
|[[:human genes:c:cmtr1|CMTR1]]|0.494|
|[[:human genes:s:stx18|STX18]]|0.493|
|[[:human genes:d:ddx55|DDX55]]|0.493|
|[[:human genes:a:abcb7|ABCB7]]|0.492|
|[[:human genes:m:march5|MARCH5]]|0.492|
|[[:human genes:s:sec61a2|SEC61A2]]|0.491|
|[[:human genes:e:ep400|EP400]]|0.491|
|[[:human genes:o:osgep|OSGEP]]|0.49|
|[[:human genes:b:brwd1|BRWD1]]|0.49|
|[[:human genes:v:vcx|VCX]]|0.488|
|[[:human genes:t:treml4|TREML4]]|0.488|
|[[:human genes:t:txnrd1|TXNRD1]]|0.486|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.484|
|[[:human genes:d:dicer1|DICER1]]|0.484|
|[[:human genes:l:lin52|LIN52]]|0.483|
|[[:human genes:a:ackr3|ACKR3]]|0.481|
|[[:human genes:t:tnfaip3|TNFAIP3]]|0.48|
|[[:human genes:u:ube2j1|UBE2J1]]|0.48|
|[[:human genes:g:gnb1l|GNB1L]]|0.48|
|[[:human genes:a:alg1|ALG1]]|0.479|
|[[:human genes:m:morc4|MORC4]]|0.478|
|[[:human genes:m:mllt1|MLLT1]]|0.478|
|[[:human genes:t:tomm40|TOMM40]]|0.478|
|[[:human genes:p:ppp4c|PPP4C]]|0.477|
|[[:human genes:s:sept9|SEPT9]]|0.474|
|[[:human genes:t:tbp|TBP]]|0.474|
|[[:human genes:n:nbn|NBN]]|0.474|
|[[:human genes:r:rbbp4|RBBP4]]|0.473|
|[[:human genes:a:abcf1|ABCF1]]|0.472|
|[[:human genes:b:brcc3|BRCC3]]|0.472|
|[[:human genes:c:ccdc101|CCDC101]]|0.471|
|[[:human genes:o:orc3|ORC3]]|0.471|
|[[:human genes:b:bak1|BAK1]]|0.471|
|[[:human genes:s:srpr|SRPR]]|0.47|
|[[:human genes:w:wdr1|WDR1]]|0.47|
|[[:human genes:m:mios|MIOS]]|0.469|
|[[:human genes:s:slmo2|SLMO2]]|0.469|
|[[:human genes:c:clcc1|CLCC1]]|0.468|
|[[:human genes:h:hist1h3e|HIST1H3E]]|0.468|
|[[:human genes:i:isca2|ISCA2]]|0.467|
|[[:human genes:t:tas2r41|TAS2R41]]|0.466|
|[[:human genes:p:pknox1|PKNOX1]]|0.463|
|[[:human genes:t:tmx2|TMX2]]|0.462|
|[[:human genes:r:rab3d|RAB3D]]|0.462|
|[[:human genes:s:snrnp35|SNRNP35]]|0.462|
|[[:human genes:d:ddx6|DDX6]]|0.46|
|[[:human genes:s:sucla2|SUCLA2]]|0.459|
|[[:human genes:d:dhx33|DHX33]]|0.458|
|[[:human genes:a:alg13|ALG13]]|0.458|
|[[:human genes:u:ubqln1|UBQLN1]]|0.458|
|[[:human genes:m:metap2|METAP2]]|0.456|
|[[:human genes:t:tti2|TTI2]]|0.456|
|[[:human genes:h:hnrnph2|HNRNPH2]]|0.456|
|[[:human genes:p:pmpca|PMPCA]]|0.455|
|[[:human genes:v:vcx3a|VCX3A]]|0.454|
|[[:human genes:s:slc38a1|SLC38A1]]|0.454|
|[[:human genes:p:pgam4|PGAM4]]|0.453|
|[[:human genes:s:slbp|SLBP]]|0.453|
|[[:human genes:p:pum1|PUM1]]|0.452|
|[[:human genes:c:chordc1|CHORDC1]]|0.452|
|[[:human genes:a:atp5j|ATP5J]]|0.451|
|[[:human genes:w:wsb2|WSB2]]|0.451|
|[[:human genes:m:mzt1|MZT1]]|0.45|
|[[:human genes:x:xpot|XPOT]]|0.45|
|[[:human genes:d:ddx19a|DDX19A]]|0.45|
|[[:human genes:v:vezt|VEZT]]|0.45|
|[[:human genes:m:manf|MANF]]|0.45|
|[[:human genes:t:tmem129|TMEM129]]|0.449|
|[[:human genes:s:snrpa|SNRPA]]|0.449|
|[[:human genes:d:dhx29|DHX29]]|0.448|
|[[:human genes:l:lrfn2|LRFN2]]|0.448|
|[[:human genes:p:pggt1b|PGGT1B]]|0.448|
|[[:human genes:z:znf460|ZNF460]]|0.448|
|[[:human genes:l:larp4b|LARP4B]]|0.448|
|[[:human genes:b:bend7|BEND7]]|0.447|
|[[:human genes:a:armc12|ARMC12]]|0.446|
|[[:human genes:p:plekhb1|PLEKHB1]]|0.446|
|[[:human genes:r:rab28|RAB28]]|0.445|
|[[:human genes:t:timm23b|TIMM23B]]|0.445|
|[[:human genes:m:mapk14|MAPK14]]|0.445|
|[[:human genes:s:slc20a1|SLC20A1]]|0.444|
|[[:human genes:t:tmem41b|TMEM41B]]|0.444|
|[[:human genes:n:nudt4|NUDT4]]|0.444|
|[[:human genes:p:prkrir|PRKRIR]]|0.444|
|[[:human genes:n:nfatc2ip|NFATC2IP]]|0.444|
|[[:human genes:s:smarcd1|SMARCD1]]|0.444|
|[[:human genes:p:preb|PREB]]|0.444|
|[[:human genes:p:ppargc1a|PPARGC1A]]|0.442|
|[[:human genes:t:txndc17|TXNDC17]]|0.442|
|[[:human genes:t:taf1b|TAF1B]]|0.442|
|[[:human genes:d:degs1|DEGS1]]|0.442|
|[[:human genes:s:srsf6|SRSF6]]|0.441|
|[[:human genes:p:psme1|PSME1]]|0.44|
|[[:human genes:p:psca|PSCA]]|0.44|
|[[:human genes:l:lsm10|LSM10]]|0.44|
|[[:human genes:d:dkc1|DKC1]]|0.44|
|[[:human genes:o:oraov1|ORAOV1]]|0.44|
|[[:human genes:l:lsm11|LSM11]]|0.439|
|[[:human genes:o:opa1|OPA1]]|0.439|
|[[:human genes:f:fbxl22|FBXL22]]|0.439|
|[[:human genes:t:tsen54|TSEN54]]|0.439|
|[[:human genes:t:top2b|TOP2B]]|0.438|
|[[:human genes:n:nsd1|NSD1]]|0.438|
|[[:human genes:y:yrdc|YRDC]]|0.438|
|[[:human genes:p:ptchd3|PTCHD3]]|0.438|
|[[:human genes:s:srp19|SRP19]]|0.437|
|[[:human genes:a:adamts1|ADAMTS1]]|0.437|
|[[:human genes:a:abcf3|ABCF3]]|0.437|
|[[:human genes:r:rbmxl2|RBMXL2]]|0.437|
|[[:human genes:p:prickle4|PRICKLE4]]|0.436|
|[[:human genes:e:eif5a|EIF5A]]|0.436|
|[[:human genes:a:afap1|AFAP1]]|0.436|
|[[:human genes:p:prmt5|PRMT5]]|0.436|
|[[:human genes:s:sec16a|SEC16A]]|0.435|
|[[:human genes:g:gtf3a|GTF3A]]|0.435|
|[[:human genes:s:sh2d4a|SH2D4A]]|0.435|
|[[:human genes:e:eftud1|EFTUD1]]|0.434|
|[[:human genes:v:vdac2|VDAC2]]|0.433|
|[[:human genes:s:ss18|SS18]]|0.433|
|[[:human genes:p:pcid2|PCID2]]|0.433|
|[[:human genes:r:ranbp10|RANBP10]]|0.432|
|[[:human genes:t:thg1l|THG1L]]|0.431|
|[[:human genes:h:hyi|HYI]]|0.431|
|[[:human genes:l:lilra2|LILRA2]]|0.429|
|[[:human genes:w:wars|WARS]]|0.429|
|[[:human genes:r:rbm20|RBM20]]|0.429|
|[[:human genes:c:csk|CSK]]|0.428|
|[[:human genes:h:hoxc13|HOXC13]]|0.428|
|[[:human genes:r:rad23b|RAD23B]]|0.428|
|[[:human genes:d:dnaja3|DNAJA3]]|0.427|
|[[:human genes:c:chmp7|CHMP7]]|0.427|
|[[:human genes:s:stt3a|STT3A]]|0.427|
|[[:human genes:s:spop|SPOP]]|0.427|
|[[:human genes:e:enosf1|ENOSF1]]|0.426|
|[[:human genes:s:slc9a8|SLC9A8]]|0.426|
|[[:human genes:g:gpnmb|GPNMB]]|0.425|
|[[:human genes:p:pkm|PKM]]|0.425|
|[[:human genes:a:aspm|ASPM]]|0.425|
|[[:human genes:c:cct8|CCT8]]|0.424|
|[[:human genes:s:serpina11|SERPINA11]]|0.424|
|[[:human genes:u:usf1|USF1]]|0.424|
|[[:human genes:p:polr3a|POLR3A]]|0.424|
|[[:human genes:m:med25|MED25]]|0.423|
|[[:human genes:z:znf609|ZNF609]]|0.422|
|[[:human genes:c:c8orf76|C8orf76]]|0.422|
|[[:human genes:i:id3|ID3]]|0.422|
|[[:human genes:a:angpt1|ANGPT1]]|0.421|
|[[:human genes:p:pabpc1|PABPC1]]|0.421|
|[[:human genes:t:trip12|TRIP12]]|0.42|
|[[:human genes:s:smg8|SMG8]]|0.42|
|[[:human genes:k:kctd5|KCTD5]]|0.418|
|[[:human genes:t:tti1|TTI1]]|0.417|
|[[:human genes:c:csnk1a1l|CSNK1A1L]]|0.417|
|[[:human genes:e:eif1ay|EIF1AY]]|0.417|
|[[:human genes:a:axin2|AXIN2]]|0.417|
|[[:human genes:e:ergic3|ERGIC3]]|0.416|
|[[:human genes:p:pde7a|PDE7A]]|0.416|
|[[:human genes:b:btbd3|BTBD3]]|0.415|
|[[:human genes:e:efr3a|EFR3A]]|0.415|
|[[:human genes:c:cyp51a1|CYP51A1]]|0.415|
|[[:human genes:n:naa35|NAA35]]|0.414|
|[[:human genes:d:dohh|DOHH]]|0.414|
|[[:human genes:r:rhot2|RHOT2]]|0.414|
|[[:human genes:c:cmip|CMIP]]|0.414|
|[[:human genes:e:eif5al1|EIF5AL1]]|0.413|
|[[:human genes:a:aup1|AUP1]]|0.413|
|[[:human genes:p:pyy|PYY]]|0.413|
|[[:human genes:t:top3a|TOP3A]]|0.413|
|[[:human genes:c:cul4a|CUL4A]]|0.413|
|[[:human genes:g:gabrd|GABRD]]|0.413|
|[[:human genes:m:micu1|MICU1]]|0.413|
|[[:human genes:f:fam153b|FAM153B]]|0.412|
|[[:human genes:c:cyp27a1|CYP27A1]]|0.412|
|[[:human genes:c:c14orf166|C14orf166]]|0.412|
|[[:human genes:f:fam71f2|FAM71F2]]|0.411|
|[[:human genes:p:phb|PHB]]|0.411|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.411|
|[[:human genes:c:csta|CSTA]]|0.41|
|[[:human genes:t:tprkb|TPRKB]]|0.41|
|[[:human genes:o:orc5|ORC5]]|0.41|
|[[:human genes:g:gemin8|GEMIN8]]|0.41|
|[[:human genes:a:anapc1|ANAPC1]]|0.409|
|[[:human genes:h:hmga1|HMGA1]]|0.409|
|[[:human genes:r:rbm14|RBM14]]|0.408|
|[[:human genes:t:trak1|TRAK1]]|0.408|
|[[:human genes:d:dnajc3|DNAJC3]]|0.408|
|[[:human genes:w:wdhd1|WDHD1]]|0.407|
|[[:human genes:s:sdhd|SDHD]]|0.407|
|[[:human genes:f:farsa|FARSA]]|0.407|
|[[:human genes:s:spata5|SPATA5]]|0.406|
|[[:human genes:f:foxk2|FOXK2]]|0.406|
|[[:human genes:a:actr6|ACTR6]]|0.404|
|[[:human genes:u:uvrag|UVRAG]]|0.404|
|[[:human genes:s:sik3|SIK3]]|0.403|
|[[:human genes:c:cebpb|CEBPB]]|0.403|
|[[:human genes:z:znf496|ZNF496]]|0.403|
|[[:human genes:p:pik3r4|PIK3R4]]|0.402|
|[[:human genes:k:klb|KLB]]|0.402|
|[[:human genes:l:lsmd1|LSMD1]]|0.402|
|[[:human genes:h:hist1h3b|HIST1H3B]]|0.401|
|[[:human genes:s:slc4a11|SLC4A11]]|0.401|
|[[:human genes:r:rbm17|RBM17]]|0.401|
|[[:human genes:r:rax|RAX]]|0.401|
|[[:human genes:r:ranbp9|RANBP9]]|0.4|
|[[:human genes:s:slc25a47|SLC25A47]]|0.4|
|[[:human genes:p:polr3d|POLR3D]]|0.4|
|[[:human genes:s:slitrk6|SLITRK6]]|0.4|
|[[:human genes:p:ppp6c|PPP6C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 700/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HARS Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>