HARS

Gene Information

Official Symbol: HARS1
Official Name: histidyl-tRNA synthetase 1
Aliases and Previous Symbols: N/A
Entrez ID: 3035
UniProt: P12081
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cytoplasmic histidine–tRNA ligase (Probable). Plays a role in axon guidance. {ECO:0000269|PubMed:26072516, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chloramphenicol 20μM R00 exp13	-2.82
BI-6727 0.0125μM R03 exp97	-2.18
Metformin 40μM R03 exp132	-2.07
PFI-3 10μM R03 exp144	-1.97
Rapamycin 1μM R00 exp29	-1.95
A-366 10μM R03 exp115	-1.87
JQ1 0.01μM R03 exp130	-1.82
Oligomycin-A 2μM R00 exp25	-1.8
Nifuroxazide 5μM R03 exp102	-1.76
CCCP 0.1μM R00 exp10	-1.73
Pimelic-diphenylamide-106 5μM R00 exp28	1.96
Rotenone 2μM R00 exp33	1.96
Nocodazole 0.2μM R00 exp24	1.97
5-Fluorouracil 20μM R00 exp2	2.34
Etoposide 1μM R00 exp19	2.88
Actinomycin-D 0.001μM R00 exp3	2.9
Rotenone 20μM R00 exp34	3.05

Gene	Correlation
CEP350	0.776
PMPCB	0.745
MEAF6	0.741
ZNF608	0.722
NARS	0.718
CCT7	0.71
PISD	0.696
GEMIN5	0.696
MARS	0.691
CCT5	0.684
NSMCE1	0.683
TGS1	0.674
PPP2R3C	0.67
KARS	0.664
GRPEL1	0.662
GABPA	0.659
EIF4E	0.659
HSPD1	0.659
TLE4	0.657
PELO	0.652
GABPB1	0.651
RPTOR	0.649
EIF2B3	0.648
TSR2	0.647
MTOR	0.645
CARS	0.642
DARS	0.641
EIF3F	0.639
CDC123	0.638
ZNF259	0.638
UBE2K	0.635
APAF1	0.635
PLAA	0.629
HCCS	0.628
TBCE	0.625
GMPPB	0.624
ENY2	0.622
PRELID1	0.622
NXT1	0.619
TAZ	0.619
GFPT1	0.617
IARS2	0.616
YARS	0.613
NSMCE2	0.61
PMM2	0.607
DHPS	0.604
USP25	0.602
CSNK2B	0.6
SPCS3	0.599
IARS	0.598
TCP1	0.598
ING3	0.594
TAMM41	0.594
UAP1	0.593
SUV420H1	0.593
DIABLO	0.59
FOXO1	0.587
GIPC2	0.587
THOC6	0.585
DPF2	0.585
NUDT10	0.584
DAD1	0.583
UHRF1	0.582
PAM16	0.581
NUPL2	0.58
VRK1	0.579
ALG11	0.578
PDCD5	0.578
DDOST	0.577
NAE1	0.576
CDC20	0.575
FARSB	0.574
SIK1	0.573
RNMT	0.573
PRR5	0.572
TBCD	0.572
CCT6A	0.571
TSEN2	0.569
AARS	0.569
SLC35B1	0.568
PCBP2	0.567
OIP5	0.567
SEH1L	0.567
FAM210A	0.567
FAF2	0.565
TIMM44	0.564
SOD2	0.564
TEN1	0.564
SRP14	0.564
ALG5	0.563
PHB2	0.562
DHDDS	0.562
ALG14	0.562
BCL7A	0.561
TBCA	0.56
TCEA3	0.558
MFN1	0.557
CRLS1	0.557
XPO5	0.556
RPE	0.554
CYCS	0.553
NUP50	0.552
EPRS	0.551
GTF3C3	0.549
HSPA9	0.547
SRP72	0.546
ALG2	0.546
TRAPPC3	0.545
OTUD5	0.544
OR6P1	0.544
CTC1	0.544
TPI1	0.544
ACTG1	0.543
CHCHD4	0.542
TRIAP1	0.54
USP48	0.54
ENO1	0.54
RPN1	0.54
GFER	0.539
GGPS1	0.539
HHEX	0.538
OGT	0.538
TMA16	0.537
IPO13	0.537
AHCY	0.537
PER2	0.536
BPIFB3	0.536
UTP23	0.535
THOC7	0.534
ERI1	0.534
SLC5A10	0.533
UBE2G1	0.533
HMGB2	0.532
MAT1A	0.53
DDX20	0.528
TXNL4B	0.527
RTCB	0.527
TRMT5	0.527
TMED9	0.527
RBMX2	0.526
GTF3C6	0.525
HIST1H3G	0.525
ARL2	0.523
VMP1	0.523
EPC2	0.523
C15orf41	0.522
UROD	0.522
BUB1	0.519
TIMM13	0.517
SSSCA1	0.517
CCT2	0.517
RABGGTB	0.517
ELF2	0.515
CASP9	0.514
SMC6	0.514
NUDT21	0.513
SPCS2	0.513
S1PR1	0.512
FLI1	0.511
MAB21L3	0.511
C8orf46	0.511
CCDC6	0.51
CDIPT	0.509
NUDT11	0.507
TSEN34	0.506
STAU1	0.506
TAF1A	0.505
XRCC2	0.505
CDKN1A	0.505
C12orf74	0.502
RAD1	0.502
ANAPC10	0.501
BAP1	0.501
TUT1	0.5
WDR24	0.499
SARS	0.497
TRIM28	0.497
APOBEC3F	0.497
TAF1C	0.497
HAUS8	0.496
UBA3	0.496
KDM6B	0.496
LOC100132813	0.495
EXOC3	0.495
POLR3B	0.494
SRP68	0.494
CMTR1	0.494
STX18	0.493
DDX55	0.493
ABCB7	0.492
MARCH5	0.492
SEC61A2	0.491
EP400	0.491
OSGEP	0.49
BRWD1	0.49
VCX	0.488
TREML4	0.488
TXNRD1	0.486
NHLRC2	0.484
DICER1	0.484
LIN52	0.483
ACKR3	0.481
TNFAIP3	0.48
UBE2J1	0.48
GNB1L	0.48
ALG1	0.479
MORC4	0.478
MLLT1	0.478
TOMM40	0.478
PPP4C	0.477
SEPT9	0.474
TBP	0.474
NBN	0.474
RBBP4	0.473
ABCF1	0.472
BRCC3	0.472
CCDC101	0.471
ORC3	0.471
BAK1	0.471
SRPR	0.47
WDR1	0.47
MIOS	0.469
SLMO2	0.469
CLCC1	0.468
HIST1H3E	0.468
ISCA2	0.467
TAS2R41	0.466
PKNOX1	0.463
TMX2	0.462
RAB3D	0.462
SNRNP35	0.462
DDX6	0.46
SUCLA2	0.459
DHX33	0.458
ALG13	0.458
UBQLN1	0.458
METAP2	0.456
TTI2	0.456
HNRNPH2	0.456
PMPCA	0.455
VCX3A	0.454
SLC38A1	0.454
PGAM4	0.453
SLBP	0.453
PUM1	0.452
CHORDC1	0.452
ATP5J	0.451
WSB2	0.451
MZT1	0.45
XPOT	0.45
DDX19A	0.45
VEZT	0.45
MANF	0.45
TMEM129	0.449
SNRPA	0.449
DHX29	0.448
LRFN2	0.448
PGGT1B	0.448
ZNF460	0.448
LARP4B	0.448
BEND7	0.447
ARMC12	0.446
PLEKHB1	0.446
RAB28	0.445
TIMM23B	0.445
MAPK14	0.445
SLC20A1	0.444
TMEM41B	0.444
NUDT4	0.444
PRKRIR	0.444
NFATC2IP	0.444
SMARCD1	0.444
PREB	0.444
PPARGC1A	0.442
TXNDC17	0.442
TAF1B	0.442
DEGS1	0.442
SRSF6	0.441
PSME1	0.44
PSCA	0.44
LSM10	0.44
DKC1	0.44
ORAOV1	0.44
LSM11	0.439
OPA1	0.439
FBXL22	0.439
TSEN54	0.439
TOP2B	0.438
NSD1	0.438
YRDC	0.438
PTCHD3	0.438
SRP19	0.437
ADAMTS1	0.437
ABCF3	0.437
RBMXL2	0.437
PRICKLE4	0.436
EIF5A	0.436
AFAP1	0.436
PRMT5	0.436
SEC16A	0.435
GTF3A	0.435
SH2D4A	0.435
EFTUD1	0.434
VDAC2	0.433
SS18	0.433
PCID2	0.433
RANBP10	0.432
THG1L	0.431
HYI	0.431
LILRA2	0.429
WARS	0.429
RBM20	0.429
CSK	0.428
HOXC13	0.428
RAD23B	0.428
DNAJA3	0.427
CHMP7	0.427
STT3A	0.427
SPOP	0.427
ENOSF1	0.426
SLC9A8	0.426
GPNMB	0.425
PKM	0.425
ASPM	0.425
CCT8	0.424
SERPINA11	0.424
USF1	0.424
POLR3A	0.424
MED25	0.423
ZNF609	0.422
C8orf76	0.422
ID3	0.422
ANGPT1	0.421
PABPC1	0.421
TRIP12	0.42
SMG8	0.42
KCTD5	0.418
TTI1	0.417
CSNK1A1L	0.417
EIF1AY	0.417
AXIN2	0.417
ERGIC3	0.416
PDE7A	0.416
BTBD3	0.415
EFR3A	0.415
CYP51A1	0.415
NAA35	0.414
DOHH	0.414
RHOT2	0.414
CMIP	0.414
EIF5AL1	0.413
AUP1	0.413
PYY	0.413
TOP3A	0.413
CUL4A	0.413
GABRD	0.413
MICU1	0.413
FAM153B	0.412
CYP27A1	0.412
C14orf166	0.412
FAM71F2	0.411
PHB	0.411
AASDHPPT	0.411
CSTA	0.41
TPRKB	0.41
ORC5	0.41
GEMIN8	0.41
ANAPC1	0.409
HMGA1	0.409
RBM14	0.408
TRAK1	0.408
DNAJC3	0.408
WDHD1	0.407
SDHD	0.407
FARSA	0.407
SPATA5	0.406
FOXK2	0.406
ACTR6	0.404
UVRAG	0.404
SIK3	0.403
CEBPB	0.403
ZNF496	0.403
PIK3R4	0.402
KLB	0.402
LSMD1	0.402
HIST1H3B	0.401
SLC4A11	0.401
RBM17	0.401
RAX	0.401
RANBP9	0.4
SLC25A47	0.4
POLR3D	0.4
SLITRK6	0.4
PPP6C	0.4

Global Fraction of Cell Lines Where Essential: 700/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/26
breast	33/33
central nervous system	54/56
cervix	4/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	16/16
kidney	19/21
liver	20/20
lung	70/75
lymphocyte	16/16
ovary	24/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	29/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 6
Expression level (log2 read counts): 6.96

Expression Distribution

tRNA-synt 2b
WHEP-TRS
HGTP anticodon2
HGTP anticodon

histidyl-tRNA aminoacylation
histidine-tRNA ligase activity
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
mitochondrial translation
mitochondrial gene expression
tRNA metabolic process
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
mitochondrion
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
gene expression