PSME1
Gene Information
- Official Symbol: PSME1
- Official Name: proteasome activator subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5720
- UniProt: Q06323
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Pfam Domains GO Terms
Pfam Domains
| PA28 alpha |
| PA28 beta |
GO Terms
| proteasome activator complex |
| endopeptidase activator activity |
| proteasome complex |
| regulation of cellular amino acid metabolic process |
| regulation of hematopoietic stem cell differentiation |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| NIK/NF-kappaB signaling |
| regulation of cellular amine metabolic process |
| anaphase-promoting complex-dependent catabolic process |
| regulation of hematopoietic progenitor cell differentiation |
| negative regulation of G2/M transition of mitotic cell cycle |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| interleukin-1-mediated signaling pathway |
| Wnt signaling pathway, planar cell polarity pathway |
| antigen processing and presentation of peptide antigen via MHC class I |
| negative regulation of cell cycle G2/M phase transition |
| regulation of establishment of planar polarity |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| regulation of stem cell differentiation |
| tumor necrosis factor-mediated signaling pathway |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of DNA-templated transcription in response to stress |
| non-canonical Wnt signaling pathway |
| positive regulation of canonical Wnt signaling pathway |
| regulation of G1/S transition of mitotic cell cycle |
| regulation of cell cycle G1/S phase transition |
| regulation of cellular ketone metabolic process |
| positive regulation of endopeptidase activity |
| Fc-epsilon receptor signaling pathway |
| cellular response to interleukin-1 |
| negative regulation of canonical Wnt signaling pathway |
| T cell receptor signaling pathway |
| antigen processing and presentation of exogenous peptide antigen |
| positive regulation of Wnt signaling pathway |
| regulation of mRNA stability |
| regulation of morphogenesis of an epithelium |
| antigen processing and presentation of exogenous antigen |
| regulation of proteasomal protein catabolic process |
| regulation of RNA stability |
| cellular response to hypoxia |
| antigen processing and presentation of peptide antigen |
| positive regulation of peptidase activity |
| regulation of G2/M transition of mitotic cell cycle |
| cellular response to decreased oxygen levels |
| response to interleukin-1 |
| regulation of mRNA catabolic process |
| negative regulation of Wnt signaling pathway |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| regulation of proteolysis involved in cellular protein catabolic process |
| antigen processing and presentation |
| negative regulation of cell cycle phase transition |
| innate immune response-activating signal transduction |
| cellular response to tumor necrosis factor |
| Fc receptor signaling pathway |
| regulation of cellular protein catabolic process |
| regulation of animal organ morphogenesis |
| activation of innate immune response |
| response to tumor necrosis factor |
| protein deubiquitination |
| regulation of canonical Wnt signaling pathway |
| antigen receptor-mediated signaling pathway |
| protein modification by small protein removal |
| protein polyubiquitination |
| negative regulation of mitotic cell cycle |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of mRNA metabolic process |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| Wnt signaling pathway |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| post-translational protein modification |
| positive regulation of response to biotic stimulus |
| MAPK cascade |
| response to oxygen levels |
| regulation of protein catabolic process |
| signal transduction by protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| regulation of endopeptidase activity |
| regulation of small molecule metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of peptidase activity |
| regulation of cell cycle phase transition |
| immune response-activating cell surface receptor signaling pathway |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| immune response-activating signal transduction |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| activation of immune response |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| regulation of proteolysis |
| regulation of cell cycle process |
| regulation of defense response |
| positive regulation of hydrolase activity |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| regulation of cellular catabolic process |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| protein phosphorylation |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| cellular response to cytokine stimulus |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of signal transduction |
| proteolysis |
| transmembrane transport |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of response to stress |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.44 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 61/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 4/28 |
| bone | 1/26 |
| breast | 4/33 |
| central nervous system | 3/56 |
| cervix | 0/4 |
| colorectal | 3/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 4/21 |
| liver | 0/20 |
| lung | 5/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 3/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 12907
- Expression level (log2 read counts): 7.23
Expression Distribution
PSME1 Expression in NALM6 Cells: 7.23
