HAS3

Entrez Summary: The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
UniProt Summary: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hyaluranon cable
regulation of hyaluranon cable assembly
extracellular polysaccharide metabolic process
extracellular polysaccharide biosynthetic process
positive regulation of hyaluranon cable assembly
hyaluronan synthase activity
hyaluronan biosynthetic process
extracellular matrix assembly
hyaluronan metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
extracellular matrix organization
extracellular structure organization
carbohydrate metabolic process
positive regulation of cellular component biogenesis
small molecule biosynthetic process
carbohydrate derivative biosynthetic process
carboxylic acid metabolic process
regulation of cellular component biogenesis
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
identical protein binding
positive regulation of cellular component organization
integral component of plasma membrane
organonitrogen compound biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription