HAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= HAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HAT1
  * **<color #00a2e8>Official Name</color>**: histone acetyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8520|8520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14929|O14929]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hat1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin silencing at telomere|
|DNA replication-dependent nucleosome organization|
|H4 histone acetyltransferase activity|
|DNA replication-dependent nucleosome assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone acetyltransferase activity|
|histone H4 acetylation|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|nuclear chromosome, telomeric region|
|nuclear matrix|
|histone acetylation|
|nucleosome assembly|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|chromatin assembly|
|protein acetylation|
|gene silencing|
|chromatin assembly or disassembly|
|nucleosome organization|
|DNA packaging|
|protein acylation|
|protein-DNA complex assembly|
|response to nutrient|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|DNA conformation change|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|response to nutrient levels|
|response to extracellular stimulus|
|protein-containing complex|
|intracellular membrane-bounded organelle|
|chromatin organization|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.19|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.88|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.72|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.75|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.76|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.84|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.88|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.88|
|[[:results:exp453|B02 10μM R08 exp453]]|1.94|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.99|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.03|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.06|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.11|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.3|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18663
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HAT1 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>