HAT1

Entrez Summary: N/A
UniProt Summary: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:9427644}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-2536 0.0042μM R03 exp95	-2.19
Parthenolide 2.5μM R05 exp238	-1.88
Curcumin 6.5μM R06 exp277	-1.72
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.71
Trimetrexate 0.03μM R08 exp535	1.75
Ibrutinib 10μM R08 exp442	1.76
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.84
Betulinic acid 10 to 15μM on day4 R05 exp222	1.88
Lead acetate 2000μM R08 exp498 no dilution day6	1.88
B02 10μM R08 exp453	1.94
ZLN024 50μM R08 exp538	1.99
HMS-I2 10μM R06 exp288	2
Trichostatin-A 0.06μM R07 exp415	2.03
Hypoxia 5%O2 R04 exp191	2.06
Cincreasin 100μM R08 exp473	2.11
RS-1 10μM R08 exp519	2.3
Bortezomib 0.005μM R00 exp6	2.73

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

chromatin silencing at telomere
DNA replication-dependent nucleosome organization
H4 histone acetyltransferase activity
DNA replication-dependent nucleosome assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
histone acetyltransferase activity
histone H4 acetylation
chromatin organization involved in negative regulation of transcription
chromatin silencing
chromatin organization involved in regulation of transcription
negative regulation of gene expression, epigenetic
nuclear chromosome, telomeric region
nuclear matrix
histone acetylation
nucleosome assembly
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
histone binding
chromatin assembly
protein acetylation
gene silencing
chromatin assembly or disassembly
nucleosome organization
DNA packaging
protein acylation
protein-DNA complex assembly
response to nutrient
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
peptidyl-lysine modification
histone modification
covalent chromatin modification
response to nutrient levels
response to extracellular stimulus
protein-containing complex
intracellular membrane-bounded organelle