HBB
Gene Information
- Official Symbol: HBB
- Official Name: hemoglobin subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 3043
- UniProt: P68871
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Globin |
GO Terms
| hemoglobin alpha binding |
| nitric oxide transport |
| hemoglobin binding |
| haptoglobin binding |
| haptoglobin-hemoglobin complex |
| organic acid binding |
| hemoglobin complex |
| oxygen carrier activity |
| oxygen transport |
| renal absorption |
| endocytic vesicle lumen |
| gas transport |
| hydrogen peroxide catabolic process |
| oxygen binding |
| peroxidase activity |
| hydrogen peroxide metabolic process |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| bicarbonate transport |
| platelet aggregation |
| positive regulation of reactive oxygen species biosynthetic process |
| antibiotic catabolic process |
| tertiary granule lumen |
| regulation of nitric oxide biosynthetic process |
| homotypic cell-cell adhesion |
| cofactor catabolic process |
| regulation of reactive oxygen species biosynthetic process |
| cellular oxidant detoxification |
| positive regulation of reactive oxygen species metabolic process |
| cellular detoxification |
| antibiotic metabolic process |
| protein heterooligomerization |
| renal system process |
| reactive oxygen species metabolic process |
| response to hydrogen peroxide |
| ficolin-1-rich granule lumen |
| detoxification |
| platelet activation |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| blood microparticle |
| heme binding |
| drug catabolic process |
| drug transport |
| vascular process in circulatory system |
| neurotransmitter transport |
| regulation of reactive oxygen species metabolic process |
| regulation of blood pressure |
| response to reactive oxygen species |
| cellular response to toxic substance |
| receptor-mediated endocytosis |
| blood coagulation |
| coagulation |
| hemostasis |
| response to antibiotic |
| regulation of neurotransmitter levels |
| response to oxidative stress |
| blood circulation |
| circulatory system process |
| cofactor metabolic process |
| organic anion transport |
| wound healing |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| drug metabolic process |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| response to toxic substance |
| leukocyte degranulation |
| regulation of anatomical structure size |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| response to inorganic substance |
| endocytosis |
| response to wounding |
| anion transport |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| import into cell |
| positive regulation of cell death |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| secretion by cell |
| response to drug |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| ion transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| extracellular space |
| regulation of cell death |
| cellular catabolic process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16604
- Expression level (log2 read counts): -4.6
Expression Distribution
HBB Expression in NALM6 Cells: -4.6
