HBEGF

Gene Information

Official Symbol: HBEGF
Official Name: heparin binding EGF like growth factor
Aliases and Previous Symbols: N/A
Entrez ID: 1839
UniProt: Q99075
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9243
Expression level (log2 read counts): 7.98

Expression Distribution

regulation of elastin biosynthetic process
negative regulation of elastin biosynthetic process
wound healing, spreading of epidermal cells
positive regulation of keratinocyte migration
negative regulation of glycoprotein biosynthetic process
regulation of keratinocyte migration
negative regulation of glycoprotein metabolic process
wound healing, spreading of cells
epiboly involved in wound healing
epiboly
ERBB2 signaling pathway
epidermal growth factor receptor binding
clathrin-coated endocytic vesicle membrane
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
negative regulation of epidermal growth factor receptor signaling pathway
morphogenesis of an epithelial sheet
epidermal growth factor receptor signaling pathway
negative regulation of ERBB signaling pathway
clathrin-coated vesicle membrane
positive regulation of wound healing
positive regulation of response to wounding
endocytic vesicle membrane
ERBB signaling pathway
regulation of epidermal growth factor receptor signaling pathway
positive regulation of smooth muscle cell proliferation
regulation of ERBB signaling pathway
regulation of smooth muscle cell proliferation
regulation of wound healing
positive regulation of epithelial cell migration
growth factor activity
positive regulation of cell growth
positive regulation of protein kinase B signaling
regulation of response to wounding
heparin binding
positive regulation of peptidyl-tyrosine phosphorylation
cell chemotaxis
regulation of epithelial cell migration
regulation of protein kinase B signaling
regulation of heart contraction