HCCS [The Human Chemical-Genetic Interaction Map Project]

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======= HCCS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HCCS
  * **<color #00a2e8>Official Name</color>**: holocytochrome c synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3052|3052]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53701|P53701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HCCS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HCCS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300056|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Links covalently the heme group to the apoprotein of cytochrome c. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyto heme lyase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-tetrapyrrole linkage|
|cytochrome c-heme linkage|
|protein-heme linkage|
|holocytochrome-c synthase activity|
|cytochrome complex assembly|
|mitochondrial inner membrane|
|cellular protein-containing complex assembly|
|animal organ morphogenesis|
|oxidation-reduction process|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.22|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.98|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.98|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.95|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.74|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.7|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.71|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.71|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.79|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.8|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.83|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.83|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.83|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.83|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.84|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.87|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.88|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.99|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.03|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.04|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.07|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.1|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.15|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.17|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.2|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.28|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.35|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.36|
|[[:results:exp539|42°C R08 exp539]]|2.38|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.41|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.43|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.44|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.55|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.56|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.57|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.57|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.58|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.6|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.67|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.73|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.73|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.86|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.91|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|3.01|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.02|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.05|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|3.07|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|3.11|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.32|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.44|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|3.49|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|3.61|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.64|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.72|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.94|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.32|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|4.6|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|4.62|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|5|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|5.04|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|5.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cycs|CYCS]]|0.762|
|[[:human genes:c:casp9|CASP9]]|0.752|
|[[:human genes:a:apaf1|APAF1]]|0.722|
|[[:human genes:b:bak1|BAK1]]|0.698|
|[[:human genes:m:march5|MARCH5]]|0.67|
|[[:human genes:t:triap1|TRIAP1]]|0.646|
|[[:human genes:d:dohh|DOHH]]|0.632|
|[[:human genes:h:hars|HARS]]|0.628|
|[[:human genes:u:uap1|UAP1]]|0.622|
|[[:human genes:u:ubqln1|UBQLN1]]|0.611|
|[[:human genes:h:hspd1|HSPD1]]|0.608|
|[[:human genes:v:vdac2|VDAC2]]|0.606|
|[[:human genes:p:plaa|PLAA]]|0.606|
|[[:human genes:t:thg1l|THG1L]]|0.596|
|[[:human genes:g:gfpt1|GFPT1]]|0.577|
|[[:human genes:a:atp5j|ATP5J]]|0.573|
|[[:human genes:g:gmppb|GMPPB]]|0.573|
|[[:human genes:e:eny2|ENY2]]|0.568|
|[[:human genes:c:crls1|CRLS1]]|0.562|
|[[:human genes:r:romo1|ROMO1]]|0.557|
|[[:human genes:d:diablo|DIABLO]]|0.555|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.554|
|[[:human genes:b:bap1|BAP1]]|0.552|
|[[:human genes:p:ppa2|PPA2]]|0.551|
|[[:human genes:t:timm13|TIMM13]]|0.547|
|[[:human genes:s:slc25a26|SLC25A26]]|0.543|
|[[:human genes:t:tufm|TUFM]]|0.543|
|[[:human genes:r:rptor|RPTOR]]|0.541|
|[[:human genes:d:dpagt1|DPAGT1]]|0.541|
|[[:human genes:p:pmm2|PMM2]]|0.54|
|[[:human genes:m:mfn1|MFN1]]|0.54|
|[[:human genes:m:mrps14|MRPS14]]|0.537|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.537|
|[[:human genes:t:tamm41|TAMM41]]|0.536|
|[[:human genes:a:atp5b|ATP5B]]|0.53|
|[[:human genes:t:taz|TAZ]]|0.529|
|[[:human genes:s:serf2|SERF2]]|0.52|
|[[:human genes:o:opa1|OPA1]]|0.513|
|[[:human genes:m:mtor|MTOR]]|0.512|
|[[:human genes:f:faf2|FAF2]]|0.503|
|[[:human genes:m:mrps34|MRPS34]]|0.501|
|[[:human genes:s:srp14|SRP14]]|0.5|
|[[:human genes:g:gfer|GFER]]|0.499|
|[[:human genes:p:pam16|PAM16]]|0.499|
|[[:human genes:m:mrpl21|MRPL21]]|0.499|
|[[:human genes:r:rpusd4|RPUSD4]]|0.498|
|[[:human genes:a:atxn10|ATXN10]]|0.497|
|[[:human genes:d:dhps|DHPS]]|0.497|
|[[:human genes:f:fech|FECH]]|0.496|
|[[:human genes:m:meaf6|MEAF6]]|0.496|
|[[:human genes:m:mrps16|MRPS16]]|0.496|
|[[:human genes:a:alg1|ALG1]]|0.496|
|[[:human genes:a:atp5a1|ATP5A1]]|0.494|
|[[:human genes:r:rnmt|RNMT]]|0.491|
|[[:human genes:r:rtcb|RTCB]]|0.491|
|[[:human genes:d:dars2|DARS2]]|0.491|
|[[:human genes:c:csnk2b|CSNK2B]]|0.49|
|[[:human genes:b:bcs1l|BCS1L]]|0.486|
|[[:human genes:c:cox16|COX16]]|0.483|
|[[:human genes:m:metap2|METAP2]]|0.482|
|[[:human genes:e:eif3f|EIF3F]]|0.481|
|[[:human genes:n:nxt1|NXT1]]|0.481|
|[[:human genes:t:thoc6|THOC6]]|0.479|
|[[:human genes:m:mrps9|MRPS9]]|0.478|
|[[:human genes:d:dap3|DAP3]]|0.476|
|[[:human genes:u:ube2k|UBE2K]]|0.476|
|[[:human genes:p:pelo|PELO]]|0.473|
|[[:human genes:a:atp5i|ATP5I]]|0.473|
|[[:human genes:p:pnpt1|PNPT1]]|0.472|
|[[:human genes:a:alg13|ALG13]]|0.472|
|[[:human genes:b:brwd1|BRWD1]]|0.471|
|[[:human genes:n:nae1|NAE1]]|0.47|
|[[:human genes:d:dhx30|DHX30]]|0.47|
|[[:human genes:n:nsd1|NSD1]]|0.469|
|[[:human genes:t:trnt1|TRNT1]]|0.467|
|[[:human genes:c:cbfb|CBFB]]|0.466|
|[[:human genes:p:pgm3|PGM3]]|0.465|
|[[:human genes:c:chchd4|CHCHD4]]|0.465|
|[[:human genes:t:tomm40|TOMM40]]|0.464|
|[[:human genes:e:elac2|ELAC2]]|0.463|
|[[:human genes:m:mrps18a|MRPS18A]]|0.463|
|[[:human genes:v:vezt|VEZT]]|0.462|
|[[:human genes:a:asxl2|ASXL2]]|0.462|
|[[:human genes:m:mrps6|MRPS6]]|0.461|
|[[:human genes:s:selrc1|SELRC1]]|0.461|
|[[:human genes:n:nupl2|NUPL2]]|0.46|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.46|
|[[:human genes:a:atp5o|ATP5O]]|0.46|
|[[:human genes:p:ppcs|PPCS]]|0.46|
|[[:human genes:m:mrp63|MRP63]]|0.46|
|[[:human genes:a:alg2|ALG2]]|0.459|
|[[:human genes:y:yars2|YARS2]]|0.459|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.459|
|[[:human genes:s:stau1|STAU1]]|0.458|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.458|
|[[:human genes:g:gabpa|GABPA]]|0.457|
|[[:human genes:n:n6amt1|N6AMT1]]|0.457|
|[[:human genes:t:tmem242|TMEM242]]|0.457|
|[[:human genes:r:rpe|RPE]]|0.457|
|[[:human genes:v:vars2|VARS2]]|0.455|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.454|
|[[:human genes:a:atp5d|ATP5D]]|0.454|
|[[:human genes:p:prkrir|PRKRIR]]|0.452|
|[[:human genes:c:cept1|CEPT1]]|0.452|
|[[:human genes:s:sars2|SARS2]]|0.45|
|[[:human genes:m:mrpl23|MRPL23]]|0.45|
|[[:human genes:k:kdsr|KDSR]]|0.45|
|[[:human genes:s:sec61g|SEC61G]]|0.449|
|[[:human genes:s:sco2|SCO2]]|0.449|
|[[:human genes:d:dhrsx|DHRSX]]|0.448|
|[[:human genes:c:c10orf2|C10orf2]]|0.448|
|[[:human genes:t:tbca|TBCA]]|0.447|
|[[:human genes:l:lsm10|LSM10]]|0.447|
|[[:human genes:r:rbmx2|RBMX2]]|0.445|
|[[:human genes:c:cct7|CCT7]]|0.444|
|[[:human genes:w:wbscr16|WBSCR16]]|0.444|
|[[:human genes:m:mrps2|MRPS2]]|0.444|
|[[:human genes:p:pik3r4|PIK3R4]]|0.444|
|[[:human genes:r:rpn1|RPN1]]|0.444|
|[[:human genes:r:rbfa|RBFA]]|0.442|
|[[:human genes:g:gfm1|GFM1]]|0.441|
|[[:human genes:f:fastkd5|FASTKD5]]|0.44|
|[[:human genes:o:oraov1|ORAOV1]]|0.44|
|[[:human genes:t:tefm|TEFM]]|0.44|
|[[:human genes:m:mrpl47|MRPL47]]|0.44|
|[[:human genes:m:mrps5|MRPS5]]|0.439|
|[[:human genes:s:ssb|SSB]]|0.439|
|[[:human genes:p:pisd|PISD]]|0.437|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.437|
|[[:human genes:a:abcf1|ABCF1]]|0.435|
|[[:human genes:t:tmem41b|TMEM41B]]|0.434|
|[[:human genes:m:mrps11|MRPS11]]|0.434|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.433|
|[[:human genes:a:adsl|ADSL]]|0.433|
|[[:human genes:m:mrps26|MRPS26]]|0.432|
|[[:human genes:u:uqcrq|UQCRQ]]|0.431|
|[[:human genes:u:ube2g2|UBE2G2]]|0.431|
|[[:human genes:p:phb|PHB]]|0.43|
|[[:human genes:m:mrpl15|MRPL15]]|0.429|
|[[:human genes:c:cox7b|COX7B]]|0.428|
|[[:human genes:u:uqcr10|UQCR10]]|0.428|
|[[:human genes:s:sec16a|SEC16A]]|0.428|
|[[:human genes:u:uba3|UBA3]]|0.427|
|[[:human genes:a:atad1|ATAD1]]|0.427|
|[[:human genes:a:alg5|ALG5]]|0.426|
|[[:human genes:a:atp5f1|ATP5F1]]|0.425|
|[[:human genes:o:oip5|OIP5]]|0.425|
|[[:human genes:d:dad1|DAD1]]|0.423|
|[[:human genes:e:exoc4|EXOC4]]|0.422|
|[[:human genes:m:mrpl53|MRPL53]]|0.422|
|[[:human genes:p:pdpk1|PDPK1]]|0.422|
|[[:human genes:g:gemin7|GEMIN7]]|0.421|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.421|
|[[:human genes:d:dr1|DR1]]|0.419|
|[[:human genes:w:wdr59|WDR59]]|0.419|
|[[:human genes:d:dpf2|DPF2]]|0.419|
|[[:human genes:a:atp5l|ATP5L]]|0.418|
|[[:human genes:u:utp23|UTP23]]|0.418|
|[[:human genes:m:mrpl20|MRPL20]]|0.417|
|[[:human genes:d:ddhd2|DDHD2]]|0.417|
|[[:human genes:a:atic|ATIC]]|0.417|
|[[:human genes:d:ddx39a|DDX39A]]|0.416|
|[[:human genes:i:id3|ID3]]|0.416|
|[[:human genes:k:kctd5|KCTD5]]|0.414|
|[[:human genes:m:mlst8|MLST8]]|0.414|
|[[:human genes:d:dnlz|DNLZ]]|0.413|
|[[:human genes:t:ttc4|TTC4]]|0.413|
|[[:human genes:a:atp5c1|ATP5C1]]|0.413|
|[[:human genes:t:trim28|TRIM28]]|0.412|
|[[:human genes:p:pdss1|PDSS1]]|0.411|
|[[:human genes:a:atp2a2|ATP2A2]]|0.411|
|[[:human genes:s:suv420h1|SUV420H1]]|0.411|
|[[:human genes:m:mrps21|MRPS21]]|0.411|
|[[:human genes:a:alas1|ALAS1]]|0.407|
|[[:human genes:c:c11orf57|C11orf57]]|0.407|
|[[:human genes:u:uhrf1|UHRF1]]|0.406|
|[[:human genes:r:rpia|RPIA]]|0.406|
|[[:human genes:a:atp5h|ATP5H]]|0.405|
|[[:human genes:r:rars2|RARS2]]|0.404|
|[[:human genes:v:vrk1|VRK1]]|0.404|
|[[:human genes:m:mrps23|MRPS23]]|0.403|
|[[:human genes:m:mrps10|MRPS10]]|0.402|
|[[:human genes:p:ppp5c|PPP5C]]|0.4|
|[[:human genes:t:tars2|TARS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HCCS Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>