HDAC11

Entrez Summary: N/A
UniProt Summary: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. {ECO:0000269|PubMed:11948178}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.81
Heregulin-B 44ng/ml R08 exp486	1.88

NAD-dependent histone deacetylase activity (H3-K14 specific)
histone H3 deacetylation
histone deacetylase activity
histone deacetylase complex
oligodendrocyte development
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
oligodendrocyte differentiation
glial cell development
glial cell differentiation
gliogenesis
transcription factor binding
histone modification
covalent chromatin modification
chromatin organization
central nervous system development
chromosome organization
neurogenesis
cell development