HDC [The Human Chemical-Genetic Interaction Map Project]

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======= HDC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HDC
  * **<color #00a2e8>Official Name</color>**: histidine decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3067|3067]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19113|P19113]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HDC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HDC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142704|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the biosynthesis of histamine from histidine. {ECO:0000269|PubMed:22767596}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyridoxal deC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histidine decarboxylase activity|
|histamine biosynthetic process|
|histamine metabolic process|
|imidazole-containing compound catabolic process|
|histidine catabolic process|
|histidine metabolic process|
|imidazole-containing compound metabolic process|
|catecholamine biosynthetic process|
|catechol-containing compound biosynthetic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|aromatic amino acid family catabolic process|
|phenol-containing compound biosynthetic process|
|aromatic amino acid family metabolic process|
|neurotransmitter biosynthetic process|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|pyridoxal phosphate binding|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|organic hydroxy compound biosynthetic process|
|ammonium ion metabolic process|
|alpha-amino acid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|cellular amino acid metabolic process|
|regulation of neurotransmitter levels|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.87|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.81|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HDC Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>