HDC

Entrez Summary: This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010].
UniProt Summary: Catalyzes the biosynthesis of histamine from histidine. {ECO:0000269|PubMed:22767596}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.015μM R05 exp208	-1.87
Dimethyloxaloylglycine 11μM R07 exp314	-1.81
Pterostilbene 16μM R02 exp78	-1.77

histidine decarboxylase activity
histamine biosynthetic process
histamine metabolic process
imidazole-containing compound catabolic process
histidine catabolic process
histidine metabolic process
imidazole-containing compound metabolic process
catecholamine biosynthetic process
catechol-containing compound biosynthetic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
aromatic amino acid family catabolic process
phenol-containing compound biosynthetic process
aromatic amino acid family metabolic process
neurotransmitter biosynthetic process
catechol-containing compound metabolic process
catecholamine metabolic process
pyridoxal phosphate binding
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
phenol-containing compound metabolic process
neurotransmitter metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
organic hydroxy compound biosynthetic process
ammonium ion metabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
regulation of neurotransmitter levels
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
carboxylic acid metabolic process
oxoacid metabolic process