HEATR1 [The Human Chemical-Genetic Interaction Map Project]

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======= HEATR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HEATR1
  * **<color #00a2e8>Official Name</color>**: HEAT repeat containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55127|55127]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H583|Q9H583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HEATR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HEATR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BP28CT|
|U3snoRNP10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|t-UTP complex|
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|90S preribosome|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|fibrillar center|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|mitochondrion|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.7|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.76|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.91|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.03|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.12|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.49|
|[[:human genes:u:utp20|UTP20]]|0.458|
|[[:human genes:p:prim1|PRIM1]]|0.435|
|[[:human genes:r:rps7|RPS7]]|0.434|
|[[:human genes:r:rps5|RPS5]]|0.425|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.424|
|[[:human genes:r:rpl6|RPL6]]|0.421|
|[[:human genes:p:psmc2|PSMC2]]|0.421|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.409|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.405|
|[[:human genes:r:rpl35|RPL35]]|0.405|
|[[:human genes:l:lad1|LAD1]]|0.405|
|[[:human genes:t:tyms|TYMS]]|0.403|
|[[:human genes:p:pwp2|PWP2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 711/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|24/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|18/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 525
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HEATR1 Expression in NALM6 Cells: 7.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>