HEATR1

Entrez Summary: N/A
UniProt Summary: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotinamide Riboside 100μM R03 exp139	1.7
Asunaprenir 3μM R07 exp336	1.76
RO-3306 3 to 4μM on day4 R04 exp165	1.91
Rifampicin 1μM R00 exp31	2.03
BI-2536 0.0042μM R03 exp95	2.12
DKK1 89ng/ml R08 exp477	2.13

Global Fraction of Cell Lines Where Essential: 711/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	24/26
breast	30/33
central nervous system	56/56
cervix	4/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	18/20
lung	72/75
lymphocyte	15/16
ovary	25/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	4/5

Expression Distribution

BP28CT
U3snoRNP10

t-UTP complex
positive regulation of rRNA processing
positive regulation of ribosome biogenesis
90S preribosome
regulation of rRNA processing
regulation of ribosome biogenesis
positive regulation of transcription by RNA polymerase I
regulation of transcription by RNA polymerase I
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
small-subunit processome
maturation of SSU-rRNA
ribosomal small subunit biogenesis
fibrillar center
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
positive regulation of cellular component biogenesis
nucleolus
RNA processing
regulation of cellular component biogenesis
mitochondrion
RNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
gene expression
positive regulation of biosynthetic process